RECRUITING

Passive Leg Raise and Mini-fluid Challenge Effect on Various Cardiac Output Surrogates for Fluid Responsiveness

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

In the critically ill population, fluid administration in an unstable patient is perhaps the most common intervention that is performed. Uncorrected hypovolemia with inappropriate vasopressors lead to organ hypoperfusion where as overzealous fluid administration especially in ARDS (Adult respiratory distress syndrome) can increase mortality. It has been estimated that only 50% of hemodynamically unstable critically ill patients are volume responsive, hence dynamic assessment of preload responsiveness has been proposed to better identify those individuals who would benefit from fluid bolus.

Official Title

Passive Leg Raise and Mini-fluid Challenge Effect on Various Cardiac Output Surrogates Such as Pulse Pressure Variation (PPV), End-tidal CO2 (Carbon Dioxide), Bioreactance (Stroke Volume Index -SVI) and Velocity Time Integral on Echocardiographic Exam for Fluid Responsiveness in Patients With Moderately Severe ARDS (Acute Respiratory Distress Syndrome)

Quick Facts

Study Start:2023-07-01
Study Completion:2025-06
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06390423

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:30 Years to 90 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Age between 30 - 90 years
  2. * Diagnosis of Vasodilatory Shock with no other obvious cause of hypotension
  3. * Diagnosis of ARDS with PF ratio \< 150 , PEEP \> 8
  4. * Patients who are under paralysis or deeply sedated, on a mechanical ventilator
  1. * Patients with arrhythmias including atrial fibrillation
  2. * Patients with chest tube, intra-abdominal hypertension or with its risk factors
  3. * Patients with structural heart disease including pulmonary hypertension (RVSP \> 45) and heart failure
  4. * Patients on extracorporeal support such as ECMO, CRRT or MCS.
  5. * Patients with COPD with a premorbid FEV1 \< 1.5 L
  6. * Severe atherosclerotic vascular disease

Contacts and Locations

Study Contact

Ramakanth Pata
CONTACT
320-240-2207
cookybrey1@gmail.com

Principal Investigator

Ramakanth Pata, MD FCCP
PRINCIPAL_INVESTIGATOR
Centracare health System

Study Locations (Sites)

St Cloud Hospital
Saint Cloud, Minnesota, 56303
United States

Collaborators and Investigators

Sponsor: CentraCare

  • Ramakanth Pata, MD FCCP, PRINCIPAL_INVESTIGATOR, Centracare health System

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-07-01
Study Completion Date2025-06

Study Record Updates

Study Start Date2023-07-01
Study Completion Date2025-06

Terms related to this study

Keywords Provided by Researchers

  • Pre-load responsiveness
  • Passive leg raise
  • Mini-fluid challenge

Additional Relevant MeSH Terms

  • Fluid Responsiveness