Prospective Multicenter Research on Donor and Recipient Management Strategies to Improve Lung Transplant Outcomes

Description

This project aims to collect detailed clinical data, blood samples, and patient-reported outcomes from 2,600 lung transplant candidates, donors, and recipients at Lung Transplant Centers. The goal is to create a robust resource for various research objectives, including studying the impact of variations in donor and medical practices on clinical outcomes. The project also seeks to identify serum biomarkers associated with or predictive of specific post-transplant complications and conditions.

Conditions

Lung Transplant; Complications, Lung Transplant; Infection or Inflammation, Lung Transplant Rejection, Lung Transplant Failure

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Study Overview

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Study Details

Study overview

This project aims to collect detailed clinical data, blood samples, and patient-reported outcomes from 2,600 lung transplant candidates, donors, and recipients at Lung Transplant Centers. The goal is to create a robust resource for various research objectives, including studying the impact of variations in donor and medical practices on clinical outcomes. The project also seeks to identify serum biomarkers associated with or predictive of specific post-transplant complications and conditions.

Prospective Multicenter Research on Donor and Recipient Management Strategies to Improve Lung Transplant Outcomes: PROMISE-Lung Study

Prospective Multicenter Research on Donor and Recipient Management Strategies to Improve Lung Transplant Outcomes

Condition
Lung Transplant; Complications
Intervention / Treatment

-

Contacts and Locations

San Francisco

University of California at San Francisco, San Francisco, California, United States, 94143

Ann Arbor

University of Michigan, Ann Arbor, Michigan, United States, 48109

Durham

Duke University Medical Center, Durham, North Carolina, United States, 27710

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Able to understand and provide informed consent
  • 2. ≥ 18 years of age at the time of written informed consent
  • 3. Anticipated listing or listed for a single or bilateral cadaveric donor lung transplant or having received a lung transplant within 30 days
  • * Participants undergoing repeat lung transplantation or multi-organ transplantation are eligible if they meet the inclusion/exclusion criteria.
  • 1. Unwillingness of a participant or legally authorized representative (LAR) to give written informed consent or comply with study protocol
  • 2. Pregnancy or plans to become pregnant
  • 3. Past or current medical problems or findings from physical examination or laboratory testing, which, in the opinion of the investigator, may pose additional risks from participation in the study, may interfere with the participant's ability to comply with study requirements or that may impact the quality or interpretation of the data obtained from the study.

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Duke University,

Scott M Palmer, MD, MHS, PRINCIPAL_INVESTIGATOR, Duke University School of Medicine, Department of Medicine

Jason D Christie, MD, MSCE, PRINCIPAL_INVESTIGATOR, University of Pennsylvania

Megan L Neely, PhD, PRINCIPAL_INVESTIGATOR, Duke University School of Medicine, Department of Biostatistics and Bioinformatics

Study Record Dates

2027-06-30