ACTIVE_NOT_RECRUITING

KYSA-5: A Study of Anti-CD19 Chimeric Antigen Receptor T-Cell (CD19 CAR T) Therapy, in Subjects With Systemic Sclerosis

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

A Study of Anti-CD19 Chimeric Antigen Receptor T Cell Therapy for Subjects with Systemic Sclerosis

Official Title

KYSA-5: A Phase 1/2, Open-Label, Multicentre Study of KYV 101, an Autologous Fully Human Anti-CD19 Chimeric Antigen Receptor T Cell (CD19 CAR T) Therapy, in Subjects With Systemic Sclerosis

Quick Facts

Study Start:2024-08-06
Study Completion:2027-03
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:ACTIVE_NOT_RECRUITING

Study ID

NCT06400303

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. Age 18 years or older
  2. Willing and able to provide informed consent
  3. Able to understand and follow study procedures
  4. Stable medical condition
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Principal Investigator

MD
STUDY_DIRECTOR
Kyverna Therapeutics, Inc.

Study Locations (Sites)

Stanford University Medical Center
Palo Alto, California, 94305
United States
Northwell Health
Great Neck, New York, 11021
United States

Collaborators and Investigators

Sponsor: Kyverna Therapeutics

  • MD, STUDY_DIRECTOR, Kyverna Therapeutics, Inc.

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-08-06
Study Completion Date2027-03

Study Record Updates

Study Start Date2024-08-06
Study Completion Date2027-03

Terms related to this study

Keywords Provided by Researchers

  • KYV-101
  • systemic sclerosis
  • autoimmune disease
  • anti-CD19 CAR-T therapy
  • cellular therapy
  • Scleroderma

Additional Relevant MeSH Terms

  • Systemic Sclerosis
  • Systemic Sclerosis - Diffuse Cutaneous
  • Systemic Sclerosis - 2013 ACR/EULAR Classification Criteria