PeRampanel fOr Status ePilEpticus pRophylaxis Post-cardiac Arrest

Description

Brain injury is the main cause of death and disability for patients surviving cardiac arrest resuscitation and seizures are diagnosed in up to a third of these patients. The investigators are proposing a pilot randomized placebo-controlled clinical trial to evaluate the safety and feasibility of perampanel use for post-cardiac arrest status epilepticus (PCARSE) prevention after cardiac arrest.

Conditions

Heart Arrest, Seizures, Status Epilepticus

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Study Overview

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Study Details

Study overview

Brain injury is the main cause of death and disability for patients surviving cardiac arrest resuscitation and seizures are diagnosed in up to a third of these patients. The investigators are proposing a pilot randomized placebo-controlled clinical trial to evaluate the safety and feasibility of perampanel use for post-cardiac arrest status epilepticus (PCARSE) prevention after cardiac arrest.

PeRampanel fOr Status ePilEpticus pRophylaxis Post-cardiac Arrest

PeRampanel fOr Status ePilEpticus pRophylaxis Post-cardiac Arrest

Condition
Heart Arrest
Intervention / Treatment

-

Contacts and Locations

San Francisco

Zuckerberg San Francisco General Hospital, San Francisco, California, United States, 94110

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age ≥18 years old
  • * Non-traumatic, out-of-hospital cardiac arrest
  • * Comatose on admission - defined as not following commands
  • * Return of spontaneous circulation (ROSC) within less than 45 minutes from the time of cardiac arrest (defined as the time of 911 or EMS (emergency medical services) witnessed arrest)
  • * Admission to the intensive care unit at Zuckerberg San Francisco General Hospital
  • * Acute cerebral hemorrhage or infarction
  • * Pregnancy
  • * Prisoner
  • * Severe kidney function impairment with creatinine clearance inferior to 30 ml/min
  • * Severe liver impairment with liver function tests five times above the upper limit of normal
  • * Electrographic or electroclinical seizures diagnosis using American Clinical Neurophysiology criteria confirmed by an epileptologist after cardiac arrest

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of California, San Francisco,

Edilberto Amorim, MD, PRINCIPAL_INVESTIGATOR, University of California, San Francisco

Study Record Dates

2026-10-20