Risk Assessment Evaluation for Identifying Participants at High Risk for Stomach Cancer

Description

This clinical trial evaluates the usefulness of various risk assessment tests, including Helicobacter pylori (H. pylori) breath testing, questionnaires, and endoscopies for identifying participants at high risk for stomach cancer. H. pylori is a bacteria that causes stomach inflammation and ulcers in the stomach. People with H. pylori infections may be more likely to develop cancer in the stomach. H. pylori breath testing can help identify the presence of H. pylori infection in a participant and help identify if the participant may be at a higher risk of developing stomach cancer. An endoscopy uses a thin, flexible lighted tube that is inserted inside the esophagus, stomach, and first part of the small intestine. This allows the doctor to see and look for abnormal areas that may need to be biopsied. Risk assessment including H. pylori evaluation, questionnaires, and endoscopies may help identify participants at high risk for stomach cancer and may be a useful screening tool for earlier stomach cancer diagnosis.

Conditions

Gastric Carcinoma

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Study Overview

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Study Details

Study overview

This clinical trial evaluates the usefulness of various risk assessment tests, including Helicobacter pylori (H. pylori) breath testing, questionnaires, and endoscopies for identifying participants at high risk for stomach cancer. H. pylori is a bacteria that causes stomach inflammation and ulcers in the stomach. People with H. pylori infections may be more likely to develop cancer in the stomach. H. pylori breath testing can help identify the presence of H. pylori infection in a participant and help identify if the participant may be at a higher risk of developing stomach cancer. An endoscopy uses a thin, flexible lighted tube that is inserted inside the esophagus, stomach, and first part of the small intestine. This allows the doctor to see and look for abnormal areas that may need to be biopsied. Risk assessment including H. pylori evaluation, questionnaires, and endoscopies may help identify participants at high risk for stomach cancer and may be a useful screening tool for earlier stomach cancer diagnosis.

My Stomach Health Project: A Pilot Study to Evaluate the Feasibility of Stomach Cancer Risk Assessment for Early Detection and Secondary Prevention

Risk Assessment Evaluation for Identifying Participants at High Risk for Stomach Cancer

Condition
Gastric Carcinoma
Intervention / Treatment

-

Contacts and Locations

Duarte

City of Hope Medical Center, Duarte, California, United States, 91010

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Documented informed consent of the participant and/or legally authorized representative
  • * Assent, when appropriate, will be obtained per institutional guidelines
  • * Age: ≥ 40 years to ≤ 80 years
  • * Identify as a racial minority either Asian, Hispanic, or Black American
  • * Willingness to:
  • * Provide blood samples and undergo upper endoscopy
  • * Identify as Non-Hispanic White
  • * History of gastric cancer
  • * Known premalignant lesions of the stomach
  • * History of upper endoscopy within 2 years
  • * Women of childbearing potential: Pregnant/ nursing
  • * An employee who is under the direct/indirect supervision of the principal investigator (PI)/a coinvestigator/the study manager
  • * A direct study team member

Ages Eligible for Study

40 Years to 80 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

City of Hope Medical Center,

Yanghee Woo, PRINCIPAL_INVESTIGATOR, City of Hope Medical Center

Study Record Dates

2026-10-09