RECRUITING

The Natural History and Biological Study of Pulmonary Recurrent Respiratory Papillomatosis (pRRP)

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Recurrent respiratory papillomatosis (RRP) is an orphan disease that affects approximately 20,000 people in the United States and is caused by infection with human papillomavirus (HPV) types 6 and 11. Since RRP is an orphan disease, it is an understudied disease entity with correspondingly few treatment options. The investigators hypothesize that by understanding the biology of RRP and the failed host immune responses against HPV, novel and rational therapies can be developed. This study will examine the genetic and immunologic alterations found in these rare tumors and distant metastatic involved sites (such as the lung) in patients diagnosed with RRP.

Official Title

The Natural History and Biological Study of Pulmonary Recurrent Respiratory Papillomatosis (pRRP)

Quick Facts

Study Start:2024-04-15
Study Completion:2030-04-15
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06412172

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 99 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * History of HPV-associated Recurrent Respiratory Papillomatosis
  2. * Has pulmonary lesions
  1. * None

Contacts and Locations

Study Contact

Sara Pai, MD, PhD
CONTACT
203-785-5820
RRPBiorepository@yale.edu
Marcelle Stiff
CONTACT
mstiffpulmonary@rrpf.org

Principal Investigator

Sara Pai
PRINCIPAL_INVESTIGATOR
Yale University

Study Locations (Sites)

Yale School of Medicine
New Haven, Connecticut, 06520
United States

Collaborators and Investigators

Sponsor: Massachusetts General Hospital

  • Sara Pai, PRINCIPAL_INVESTIGATOR, Yale University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-04-15
Study Completion Date2030-04-15

Study Record Updates

Study Start Date2024-04-15
Study Completion Date2030-04-15

Terms related to this study

Additional Relevant MeSH Terms

  • Recurrent Respiratory Papillomatosis
  • Pulmonary Neoplasm