CBD for Knee Osteoarthritis

Description

Osteoarthritis is a disease that affects millions of Americans and is the leading cause of persistent pain and physical disability in the older adult population. Many physically active Americans have reported pain-relieving effects of cannabidiol (CBD) that can reduce or eliminate use of nonsteroidal anti-inflammatory drugs (NSAIDs) for activity-related pain with minimal to no side effects. Long-term use of over-the-counter medications, including NSAIDs, can pose a significant health risk, and therefore clinical research on the safety and efficacy of CBD is needed.

Conditions

Osteoarthritis, Knee

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Study Overview

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Study Details

Study overview

Osteoarthritis is a disease that affects millions of Americans and is the leading cause of persistent pain and physical disability in the older adult population. Many physically active Americans have reported pain-relieving effects of cannabidiol (CBD) that can reduce or eliminate use of nonsteroidal anti-inflammatory drugs (NSAIDs) for activity-related pain with minimal to no side effects. Long-term use of over-the-counter medications, including NSAIDs, can pose a significant health risk, and therefore clinical research on the safety and efficacy of CBD is needed.

Sub-Lingual Administration of Cannabidiol for Knee Osteoarthritis

CBD for Knee Osteoarthritis

Condition
Osteoarthritis, Knee
Intervention / Treatment

-

Contacts and Locations

Gainesville

Sports Medicine Research Laboratory, Gainesville, Florida, United States, 32601

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. established clinical diagnosis of knee osteoarthritis (KOA)
  • 2. moderate to severe knee pain (≥4/10) with physical activity in one or both knees
  • 1. pregnant (urine pregnancy test) or lactating
  • 2. current cannabis (THC and/or CBD) use (urine drug screen)
  • 3. any prior or ongoing medical condition that, in the investigators' opinion, could adversely affect the safety of the subject
  • 4. any major surgery within 3 months prior to recruitment or planned orthopedic surgery for any time during this study which would interfere with the ability to report pain or quality of life outcome measures
  • 5. any exposure to another investigational drug within 3 months prior to screening
  • 6. BMI ≥ 45
  • 7. current use of any enzyme-modifying drugs, including strong inhibitors or strong inducers of cytochrome P (CYP) enzymes
  • 8. history of:
  • 1. suicidal ideation or self-harm behavior
  • 2. seizure disorder or traumatic brain injury,
  • 3. liver or kidney disease, and
  • 4. cardiovascular diseases

Ages Eligible for Study

40 Years to 75 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Florida,

Study Record Dates

2026-12-31