Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
For general information about clinical research, read Learn About Studies.
Eligibility Criteria
- * Males and females between 18 and 65 years of age who are able to comprehend instructions, follow study procedures, willing to sign an informed consent form, and consume an isoenergetic diet eating all meals from Mayo Clinical Research and Trials Unit for at least 3 days prior to study.
- * Overweight/Obese volunteers will have a BMI 29.0 - 40.0 kg/m2
- * Female subjects are eligible if they meet the following criteria:
- * Are not pregnant or nursing
- * All women of childbearing potential will have a negative urine pregnancy test at screening and a negative urine pregnancy test within 48 hours before administering study drug.
- * Recent or current research participation in a study that involves an investigational drug. Participants in other clinical trials that involve an investigational drug will not be able to participate in this study until 12 weeks after their participation in the other study is complete or \> than five half-lives of the compound, whichever is longer. If Yes look at consent form and f/u visits:
- * Current use of medications that alter fatty acid or adipose metabolism possibly given: if yes, exclude
- * Amount of blood drawn during the study (if our study plus this one draw ≥ 450 ml these should be separated by 8 weeks
- * Previous labs:
- * Fasting glucose \< 126 mg/dl for non-diabetic UBO
- * Hb ≥ 11.0 for women and ≥ 12 for men
- * platelets \> 100 000
- * Individuals with a history of a disease process such as:
- * Ischemic heart disease
- * Atherosclerotic valvular disease
- * Persistent blood pressure greater than 160/95 despite antihypertensive medication
- * Peripheral artery disease
- * Any history of trans-ischemic attacks.
- * Coronary artery disease.
- * Liver cirrhosis
- * Significant renal impairment as documented in medical chart.
- * Smokers
- * Diagnosis of Diabetes Mellitus.
- * Concomitant use of medications that can alter free fatty acid metabolism or pose a drug-drug interaction: statins (if yes hold for 4 weeks and receive primary care provider's approval); Niacin; Fibrates; thiazolidinedione; Beta-blockers; Oral or injected corticosteroids or anabolic steroids; Linezolid; Dihydroergotamine; Phenelzine; daily phosphodiesterase inhibitors
- * Allergy to lidocaine
- * Allergy to indocyanine green.
Ages Eligible for Study
18 Years to 65 Years
Sexes Eligible for Study
ALL
Accepts Healthy Volunteers
Yes