RECRUITING

Evaluating Fluid Responsiveness in ICU Patients Using VTI and Trendelenburg Positioning

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Fluid administration is a commonly performed in the ICU for critically ill patients. However, it can lead to complications such as fluid overload, pulmonary edema, and increased mortality in some patients. Therefore, identifying patients who are likely to respond to fluid therapy is crucial for optimizing their management. Several methods have been used to assess fluid responsiveness, such as passive leg raising, stroke volume variation, and cardiac output monitoring. However, these methods have limitations and may not be feasible in all patients. In this study, the investigators aim to evaluate the use of velocity time integral (VTI) and Trendelenburg positioning in predicting fluid responsiveness in ICU patients.

Official Title

Evaluating Fluid Responsiveness in Intensive Care Unit Patients Using VTI and Trendelenburg Positioning. TREND-US Trial.

Quick Facts

Study Start:2024-04-01
Study Completion:2025-08-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06418022

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Adult patients (≥ 18 years old) admitted to the medical or surgical ICU.
  2. * Patients who require fluid administration for suspicion of hypovolemia or indicated for volume expansion due to any one of the following: hypotension (systolic blood pressure \< 90 mm Hg or mean arterial pressure \< 65 mm Hg), tachycardia (heart rate \> 100 beats per min), blood lactate \> 2.0 mmol/L, skin mottling, oliguria (urine output \< 30 ml/hr), or requiring vasopressor/inotrope support.
  3. * Patients who are able to tolerate the Trendelenburg position.
  1. * Pregnancy.
  2. * Prisoners and institutionalized patients.
  3. * Patients who are not able to tolerate the Trendelenburg position. This includes patients with increased intra-cranial hypertension, intra-abdominal hypertension and gastric retention which places a risk for stomach fluid aspiration.
  4. * Unsatisfactory cardiac echogenicity (an inability to correctly align the Doppler beam to generate reliable VTI measurements at the left ventricular outflow tract \[LVOT\]).

Contacts and Locations

Study Contact

Matthew Kheir, MD
CONTACT
516-465-1910
mkheir1@northwell.edu
Sara Velichkovikj, BS
CONTACT
212-434-4087

Principal Investigator

Matthew Kheir, MD
PRINCIPAL_INVESTIGATOR
Lenox Hill Hospital- Northwell Health

Study Locations (Sites)

Lenox Hill Hospital- Northwell Health
New York, New York, 10075
United States

Collaborators and Investigators

Sponsor: Lenox Hill Hospital

  • Matthew Kheir, MD, PRINCIPAL_INVESTIGATOR, Lenox Hill Hospital- Northwell Health

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-04-01
Study Completion Date2025-08-01

Study Record Updates

Study Start Date2024-04-01
Study Completion Date2025-08-01

Terms related to this study

Keywords Provided by Researchers

  • fluid
  • responsiveness
  • VTI
  • ICU
  • POCUS
  • ultrasound
  • Trendelenburg

Additional Relevant MeSH Terms

  • Shock
  • Fluid Overload
  • Cardiac Output, Low