Effectiveness of a Butyrate Formulation and Butyrate + Polyphenol Formulation on Gut Health, Permeability and Associated Symptoms

Eligibility Criteria

• 1. Ambulatory, male or female, 21-70 years of age
• 2. A BMI of 18.5 -34.9
• 3. . Experiences at least three conditions involving gastrointestinal health on a weekly basis
• 4. Are comfortable fasting overnight
• 5. Are able to complete study procedures for up to approximately 6 hours on 2 separate days
• 6. Considered to be generally healthy on the basis of medical history
• 7. Willing to follow study instructions, including compliance with the study procedures and requirements
• 1. Unable to provide a urine specimen, stool specimen or blood sample from a finger stick
• 2. Currently on a galactose/lactose restricted diet
• 3. Having taken proton pump inhibitors within the past 3 months
• 4. History of oral antibiotic use within the past 3 months
• 5. Current or previous history of gastrointestinal disease, cancer, infection or surgery that may interfere with the outcome parameters
• 6. A medical or surgical event requiring hospitalization, outpatient visits or emergency room visits within the past 5 years or in the judgment of the Study Investigator /Sub-I would preclude participation in the study
• 7. Current or previous history of diabetes
• 8. History of a major change in dietary habits with the past 1 month
• 9. Known intolerance or allergy to sugar alcohols including mannitol, sorbitol, xylitol, lactulose or lactose
• 10. Women who are lactating, pregnant or planning pregnancy within the next two months
• 11. Having donated blood or received a blood transfusion within 30 days before screening
• 12. Currently participating in another clinical research study or participated in another clinical research study within 30 days prior to screening