RECRUITING

Resistance Exercise and Creatine in Colorectal Cancer

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

skeletal muscle mass and function, is prevalent in up to 60% of colorectal cancer patients. This condition arises from a combination of factors such as aging, inactivity, treatment side effects, malnutrition, tumor burden, and inflammation. Given this complexity, singular interventions may not be sufficient to address sarcopenia in this group. Creatine monohydrate, a compound vital for energy during exercise, has been extensively researched and proven safe and effective across various demographics, including older adults and clinical populations. Studies show that creatine enhances benefits from resistance training, indicating potential to counter muscle mass and function decline post-cancer treatment. This study aims to assess the feasibilty of combining creatine supplementation with resistance training versus resistance training alone in sarcopenic colorectal cancer survivors. A randomized controlled pilot trial will compare a 10-week program of resistance exercise plus creatine (EXSUPP) with resistance exercise alone (EXPLA), each with 20 participants.

Official Title

The Feasibility and Acceptability of Resistance Training and Creatine Supplementation to Promote Physical Function in Sarcopenic Colorectal Cancer Survivors

Quick Facts

Study Start:2024-01-09
Study Completion:2025-07-22
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06420726

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * . Individuals ≥12 months post treatment for colorectal cancer
  2. * \>18 years
  1. 1. are receiving active treatment for their cancer;
  2. 2. have a any contraindication to exercise participation;
  3. 3. have been participating in structured resistance exercise 2 or more times per week for the past 6 months;
  4. 4. are currently taking supplements containing creatine for 4 weeks prior to the start of the RCT, or
  5. 5. are receiving medications that might alter body composition (metformin, corticosteroids etc.).

Contacts and Locations

Study Contact

Ciaran Fairman
CONTACT
803-576-8397
cfairman@mailbox.sc.edu
Alex Brooks
CONTACT
amb91@email.sc.edu

Principal Investigator

Ciaran Fairman, PhD
PRINCIPAL_INVESTIGATOR
University of South Carolina

Study Locations (Sites)

University of South Carolina
Columbia, South Carolina, 29201
United States

Collaborators and Investigators

Sponsor: University of South Carolina

  • Ciaran Fairman, PhD, PRINCIPAL_INVESTIGATOR, University of South Carolina

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-01-09
Study Completion Date2025-07-22

Study Record Updates

Study Start Date2024-01-09
Study Completion Date2025-07-22

Terms related to this study

Additional Relevant MeSH Terms

  • Colorectal Cancer