RECRUITING

Efficacy of Targeted Medical Therapy in Angina and Nonobstructive Coronary Arteries

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this clinical trial is to learn if targeted medical therapy will improve symptoms and quality of life in patients with angina and non-obstructive coronary arteries compared to placebo, after the underlying cause of the chest pain has been ascertained by coronary function testing. Participants will be treated with either medications that target the underlying cause of their chest pain or placebo for 4 weeks after a drug titration phase of 1-3 weeks. They will be asked to complete a series of questionnaires to evaluate their quality of life at the beginning and end of the study.

Official Title

A Randomized Controlled Study of Targeted Medical Therapy Versus Placebo for Angina and Non- Obstructive Coronary Arteries: The MVP-ANOCA Study

Quick Facts

Study Start:2024-10-10
Study Completion:2026-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06424834

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * All patients with stable angina referred to the Stanford University Hospital cardiac catheterization laboratory for clinically indicated coronary function testing are eligible for inclusion into the study.
  2. * Absence of significant epicardial coronary artery disease on angiography
  3. * Fractional flow reserve \> 0.80
  4. * Epicardial coronary spasm on acetylcholine testing
  5. * Microvascular spasm on acetylcholine testing
  6. * Coronary flow reserve \< 2.5
  7. * Index of microcirculatory resistance ≥ 25
  8. * Myocardial bridge on intravascular ultrasound with dobutamine resting full-cycle ratio ≤ 0.76
  1. * Acute coronary syndrome less than one week prior to enrolment
  2. * Cardiomyopathy
  3. * Contraindications to beta-blockers or calcium channel blockers
  4. * Baseline systolic blood pressure \< 95 mmHg
  5. * Baseline heart rate \< 55 bpm

Contacts and Locations

Study Contact

Christopher Wong, MBBS, PhD
CONTACT
(650) 725 5909
ccywong@stanford.edu

Principal Investigator

Jennifer Tremmel, MD
PRINCIPAL_INVESTIGATOR
Stanford University

Study Locations (Sites)

Stanford Hospital
Palo Alto, California, 94304
United States

Collaborators and Investigators

Sponsor: Stanford University

  • Jennifer Tremmel, MD, PRINCIPAL_INVESTIGATOR, Stanford University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-10-10
Study Completion Date2026-12

Study Record Updates

Study Start Date2024-10-10
Study Completion Date2026-12

Terms related to this study

Additional Relevant MeSH Terms

  • Angina Pectoris
  • Microvascular Angina
  • Vasospastic Angina
  • Myocardial Bridge of Coronary Artery