A Study to Evaluate the Efficacy and Safety of Bimekizumab Compared to Ustekinumab in Children and Adolescents From 6 Years to Less Than 18 Years of Age With Moderate to Severe Plaque Psoriasis

Eligibility Criteria

• * Study participant must be 6 to \<18 years of age, inclusive, at the time of signing the informed consent/assent according to local regulation
• * Study participant has had a diagnosis of moderate to severe plaque psoriasis (PSO) for at least 3 months prior to the Screening Visit
• * Study participant meets the following at both the Screening and Baseline Visits:
• 1. Body surface area (BSA) affected by PSO ≥10%
• 2. . Investigator's Global Assessment (IGA) score ≥3 (on a scale from 0 to 4)
• 3. . Psoriasis Area and Severity Index (PASI) score ≥12 OR
• * Study participant is a candidate for systemic PSO therapy and/or photo/chemotherapy and for treatment with ustekinumab per labeling
• * Study participant has body weight ≥15 kg and body mass index for age percentile of ≥5 at Screening
• * Primary failure (no response within 12 weeks) to 1 or more interleukin-17 (IL-17) biologic response modifiers (eg, brodalumab, ixekizumab, secukinumab) OR more than 1 biologic response modifier other than an IL-17
• * Study participant has a presence of guttate, inverse, pustular, or erythrodermic PSO or other dermatological condition that may impact the clinical assessment of PSO
• * Study participant has a history of inflammatory bowel disease (IBD) or symptoms suggestive of IBD
• * History of active tuberculosis unless successfully treated, latent TB unless prophylactically treated
• * Study participant has an active infection or history of infections (such as serious infection, chronic infections, opportunistic infections, unusually severe infections)
• * Study participant has previously received bimekizumab
• * Study participant has previously received ustekinumab
• * Study participant has received drugs outside the specified timeframes relative to the Baseline Visit or receives prohibited concomitant treatments
• * Study participant has the presence of active suicidal ideation, or positive suicide behavior
• * Study participant diagnosed with severe depression in the past 6 months (prior to Screening) should be excluded
• * Study participant has a history of psychiatric inpatient hospitalization within the past year before enrolling into the study