tFUS Induced Transient Scotoma for Individual Dosing

Description

The purposes of this research study is to: 1. Develop a technique of transcranial Focused Ultrasound Stimulation (tFUS) where meaningful effects on the brain can be easily measured. 2. Use this technique to measure threshold for effective tFUS in individuals. 3. Determine whether disruption of conscious visual detection, versus non-conscious visually-guided behavior have different thresholds for disruption with tFUS.

Conditions

Healthy

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Study Overview

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Study Details

Study overview

The purposes of this research study is to: 1. Develop a technique of transcranial Focused Ultrasound Stimulation (tFUS) where meaningful effects on the brain can be easily measured. 2. Use this technique to measure threshold for effective tFUS in individuals. 3. Determine whether disruption of conscious visual detection, versus non-conscious visually-guided behavior have different thresholds for disruption with tFUS.

Developing a Method of Adjusting the Strength of Transcranial Focused Ultrasound (tFUS) to Personalize Treatment.

tFUS Induced Transient Scotoma for Individual Dosing

Condition
Healthy
Intervention / Treatment

-

Contacts and Locations

Charleston

Medical University of South Carolina Brain Stimulation Division, Charleston, South Carolina, United States, 29425

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Male or female
  • * Age 18-70
  • * Normal or corrected-to normal vision and hearing
  • * No neurological or psychological illness
  • * Diagnosis of any depressive or anxiety disorder
  • * Diagnosis of schizophrenia or bipolar disorder
  • * Current use of any non-prescribed psychoactive medications or drugs
  • * Contraindication to enter the MRI environment.
  • * Pregnancy (or suspected/possible pregnancy or plan to become pregnant in the short term).
  • * Urine Pregnancy Test: If the subject is a woman of childbearing potential and /or a man capable of fathering a child before, during, and/or after participation precaution should be taken. Examples of acceptable methods of birth control for participants involved in the study include: birth control pills, patch, IUD, condom, sponge, diaphragm with spermicide, or avoiding sexual activity that could cause the subject to become pregnant.
  • * Inability to adhere to treatment schedule.
  • * Initiation of new antidepressant treatment at the time of study randomization.

Ages Eligible for Study

18 Years to 70 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Medical University of South Carolina,

Study Record Dates

2025-08-20