Chest Drain Regular Flushing in Complicated Parapneumonic Effusions and Empyemas

Description

Infections of the pleural space are common, and patients require antibiotics and chest drain placement to evacuate the chest from the infected fluid. Chest drains can get blocked by the drainage fluid and material. For this reason, it is thought that flushing the chest drain with saline solution, can help maintain the patency of the tube. This proposed study will evaluate the impact of regular chest drain flushing on the length of time to chest tube removal and total hospitalization as well as improvement in chest imaging and the need for additional interventions on the infected space.

Conditions

Empyema, Pleural, Pleural Infection

Study Overview

Study Details

Study overview

Infections of the pleural space are common, and patients require antibiotics and chest drain placement to evacuate the chest from the infected fluid. Chest drains can get blocked by the drainage fluid and material. For this reason, it is thought that flushing the chest drain with saline solution, can help maintain the patency of the tube. This proposed study will evaluate the impact of regular chest drain flushing on the length of time to chest tube removal and total hospitalization as well as improvement in chest imaging and the need for additional interventions on the infected space.

Chest Drain Regular Flushing in Complicated Parapneumonic Effusions and Empyemas

Chest Drain Regular Flushing in Complicated Parapneumonic Effusions and Empyemas

Condition
Empyema, Pleural
Intervention / Treatment

-

Contacts and Locations

Nashville

Vanderbilt University Medical Center, Nashville, Tennessee, United States, 37203

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Patients with complicated parapneumonic pleural effusion and empyema requiring chest tube placement as standard of care for inpatient management of their pleural space infection with or without intrapleural tissue plasminogen activator and deoxyribonuclease therapy
  • * Age \> 18 years old.
  • * Patients who have surgical tubes that can't accommodate a three-way stopcock.
  • * Study subject has any disease or condition that interferes with the safe completion of the study.
  • * Inability to provide informed consent.
  • * Inability to undergo a chest X-ray.
  • * If the managing clinician believes the chest tube will be placed for less than 24 hours.
  • * Patients with an indwelling pleural catheter (IPC)

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Vanderbilt University Medical Center,

Jennifer D Duke, MD, STUDY_DIRECTOR, Vanderbilt University

Study Record Dates

2025-10-30