Levothyroxine Supplementation for Heart Transplant Recipients

Description

This will be a prospective, randomized study performed at a single tertiary referral academic medical center (University of California San Francisco, CA), evaluating the survival benefits of levothyroxine compared with no levothyroxine for patients who have undergone heart transplant. It will be double-blinded and placebo-control; participants will be randomized to receive levothyroxine or receive no levothyroxine.

Conditions

Heart Transplant Failure, Heart Transplant Infection

Study Overview

Study Details

Study overview

This will be a prospective, randomized study performed at a single tertiary referral academic medical center (University of California San Francisco, CA), evaluating the survival benefits of levothyroxine compared with no levothyroxine for patients who have undergone heart transplant. It will be double-blinded and placebo-control; participants will be randomized to receive levothyroxine or receive no levothyroxine.

Levothyroxine Supplementation for Heart Transplant Recipients: A Randomized Control Trial

Levothyroxine Supplementation for Heart Transplant Recipients

Condition
Heart Transplant Failure
Intervention / Treatment

-

Contacts and Locations

San Francisco

University of California, San Francisco, San Francisco, California, United States, 94143

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Participants must be listed for heart transplantation
  • 2. Age ≥18 years
  • 3. Ability to understand and the willingness to sign a written informed consent document.
  • 1. Patients with pre-existing thyroid related condition including hypothyroidism, hyperthyroidism and malignancy
  • 2. Patients with a known allergy or intolerance to levothyroxine
  • 3. Patients participating in another study evaluating an investigational drug within the past 30 days.

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of California, San Francisco,

Jason Smith, MD, PRINCIPAL_INVESTIGATOR, University of California, San Francisco

Study Record Dates

2027-03-01