RECRUITING

Effect of Nitropaste in Chest Masculinizing Surgery

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Nitropaste is a topical agent that contains 2% nitroglycerin. It is an effective vascular smooth dilator, with more powerful effect on venous vasculature than arterial vasculature. While its main indication is for angina pectoris, there have been many studies showing improved survival of axial and random pattern flaps. Furthermore, recent clinical studies highlight significantly decreased mastectomy flap wound complication and need for sharp debridement. Nitropaste has low rates of side effects and is very well tolerated in general. To this date, there's no study that investigates its utility on patients who are undergoing chest masculinizing surgery. The purpose of this study is to investigate the potential utility of nitropaste in reducing rates of wound complications in patients undergoing chest masculinizing surgery.

Official Title

The Effect of Nitropaste in Chest Masculinizing Surgery: Randomized, Prospective Trial

Quick Facts

Study Start:2022-08-15
Study Completion:2025-11
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06428669

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:FEMALE
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Any adult (18 or older) patients of any gender identity who are undergoing chest masculinizing surgery with double incision and free nipple grafting.
  1. * Minor patients (younger than 18)
  2. * Anyone who's not getting free nipple grafting
  3. * Anyone who's not utilizing double incision pattern
  4. * Prisoners, anyone who is allergic to nitropaste
  5. * Anyone who is taking phosphodiesterase inhibitor (ex)Sildenafil, tadalafil, vardenafil)
  6. * Anyone who's taking soluble guanylate cyclase stimulator riociguatdz

Contacts and Locations

Study Contact

Rachel H Park, MD
CONTACT
434-327-2140
rhp7gu@hscmail.mcc.virginia.edu

Principal Investigator

John T Stranix, MD
PRINCIPAL_INVESTIGATOR
UVA

Study Locations (Sites)

University of Virginia Medical Center
Charlottesville, Virginia, 22902
United States

Collaborators and Investigators

Sponsor: University of Virginia

  • John T Stranix, MD, PRINCIPAL_INVESTIGATOR, UVA

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-08-15
Study Completion Date2025-11

Study Record Updates

Study Start Date2022-08-15
Study Completion Date2025-11

Terms related to this study

Keywords Provided by Researchers

  • Gender affirming surgery
  • Chest masculinizing Surgery
  • Nitropaste
  • Wound healing

Additional Relevant MeSH Terms

  • Gender Dysphoria