The Preventive Role of Fractionated Laser Resurfacing Against Actinic Neoplasia in an At-Risk Geriatric Population

Description

The purpose of this study is to determine if the Fractionated Laser Resurfacing (FLR) procedure can protect one forearm/wrist from precancerous actinic keratosis (AKs) as well as prevent skin cancer in older subjects with active AKs. This study builds on a similar study ongoing at the Dayton Veterans Administration dermatology clinic. This study is also testing if a photograph of the skin can be used to predict where the AKs and an skin cancers will form.

Conditions

Actinic Keratoses, Aging, Non-Melanoma Skin Cancer

Study Overview

Study Details

Study overview

The purpose of this study is to determine if the Fractionated Laser Resurfacing (FLR) procedure can protect one forearm/wrist from precancerous actinic keratosis (AKs) as well as prevent skin cancer in older subjects with active AKs. This study builds on a similar study ongoing at the Dayton Veterans Administration dermatology clinic. This study is also testing if a photograph of the skin can be used to predict where the AKs and an skin cancers will form.

The Preventive Role of Fractionated Laser Resurfacing Against Actinic Neoplasia in an At-Risk Geriatric Population

The Preventive Role of Fractionated Laser Resurfacing Against Actinic Neoplasia in an At-Risk Geriatric Population

Condition
Actinic Keratoses
Intervention / Treatment

-

Contacts and Locations

Fairborn

Wright State Physicians, Fairborn, Ohio, United States, 45324

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Adult Males and Females aged 60 and older
  • * Have at least 5 AKs on each forearm/wrist, but no more than 10 to allow for easy monitoring
  • * Skin type fair (Fitzpatrick I-II)
  • * Females must be post-menopausal and not be on systemic hormone replacement therapy
  • * Able to comprehend procedures and risks
  • * More than 10 AKs on an extremity
  • * AKs that are large (2-3+, hyperkeratotic grade 3 lesions)
  • * AKs that are very thick (\>3 mm)
  • * Medical history of diabetes
  • * History of poor wound healing or scarring
  • * Large tattoos that can interfere with study
  • * Other serious health issues and other skin diseases that could interfere with the study
  • * Recent (within 1 year) field therapies such as efudex cream or PDT to forearms/wrists.
  • * Planning to leave region in next 5 years
  • * Subjects with allergies to xylocaine will be excluded if they need this topical anesthetic.

Ages Eligible for Study

60 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Wright State University,

Jeffrey Travers, MD, PhD, PRINCIPAL_INVESTIGATOR, Wright State University

Study Record Dates

2031-12