Time Restricted Eating in Alzheimer's Disease (TREAD)

Description

This pilot and feasibility study will enable the research team to determine the feasibility of implementing a time-restricted eating regimen among adults with mild cognitive impairment (MCI) and the impact of time-restricted eating on cognitive performance and biomarkers of metabolic health in this population. Study staff will execute the specific aims using a pre-post, non-randomized study design in which all participants receive the intervention. The intervention is a 16/8 time-restricted eating regimen characterized by fasting for 16 hours and eating within an 8-hour window on 5 days per week for 3 months. Assessments will be performed at baseline and after the 3-month time-restricted eating intervention with the following outcome measures. Outcome measures for feasibility include participant recruitment, retention and metrics of acceptability, safety, and adherence to the intervention. Outcome measures for cognitive performance and metabolic health include neuropsychological tests, blood biomarkers, and surveys of psychological well-being.

Conditions

Mild Cognitive Impairment (MCI)

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Study Overview

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Study Details

Study overview

This pilot and feasibility study will enable the research team to determine the feasibility of implementing a time-restricted eating regimen among adults with mild cognitive impairment (MCI) and the impact of time-restricted eating on cognitive performance and biomarkers of metabolic health in this population. Study staff will execute the specific aims using a pre-post, non-randomized study design in which all participants receive the intervention. The intervention is a 16/8 time-restricted eating regimen characterized by fasting for 16 hours and eating within an 8-hour window on 5 days per week for 3 months. Assessments will be performed at baseline and after the 3-month time-restricted eating intervention with the following outcome measures. Outcome measures for feasibility include participant recruitment, retention and metrics of acceptability, safety, and adherence to the intervention. Outcome measures for cognitive performance and metabolic health include neuropsychological tests, blood biomarkers, and surveys of psychological well-being.

Time-Restricted Eating in Alzheimer's Disease : the T.R.E.A.D Trial

Time Restricted Eating in Alzheimer's Disease (TREAD)

Condition
Mild Cognitive Impairment (MCI)
Intervention / Treatment

-

Contacts and Locations

Phoenix

Arizona State University, College of Health Solutions, Phoenix, Arizona, United States, 85004

Phoenix

Barrow Neurological Institute, Division of Alzheimer's Disease, Phoenix, Arizona, United States, 85013

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. aged 60-80 years
  • 2. meet criteria for MCI
  • 3. body mass index \>18.5 and \<40.0 kg/m2
  • 4. access to the internet through computer or smart phone
  • 5. supportive family member (e.g., spouse or adult child) who will help to facilitate study visits and intervention activities
  • 6. education level \> 8 years
  • 7. proficiency in speaking and reading English or having a family member who is proficient in reading and speaking English and is willing to serve as a translator.
  • 1. diabetes mellitus that requires insulin treatment or is not well managed
  • 2. eating disorder
  • 3. contraindication to time-restricted eating

Ages Eligible for Study

60 Years to 80 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

St. Joseph's Hospital and Medical Center, Phoenix,

Yonas E Geda, MD, MSc, PRINCIPAL_INVESTIGATOR, Barrow Neurological Institute, Alzheimer's Disease and Cognitive Disorders Division

Study Record Dates

2026-03-14