The major goal of this study is to determine the incidence of adrenal insufficiency in patients with endogenous Cushing syndrome receiving osilodrostat treatment combined with a replacement of glucocorticoid (block-and-replace approach). The investigators are also evaluating new biomarker steroids to reflect adequate osilodrostat dosing, the durability and safety, and clinical improvement during treatment.
Endogenous Cushing Syndrome, Adrenal Insufficiency, Hypercortisolism
The major goal of this study is to determine the incidence of adrenal insufficiency in patients with endogenous Cushing syndrome receiving osilodrostat treatment combined with a replacement of glucocorticoid (block-and-replace approach). The investigators are also evaluating new biomarker steroids to reflect adequate osilodrostat dosing, the durability and safety, and clinical improvement during treatment.
A Block-and-Replace Therapy With Osilodrostat and Concomitant Glucocorticoid Replacement
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University of Michigan, Ann Arbor, Michigan, United States, 48109
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
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18 Years to 75 Years
ALL
No
University of Michigan,
Richard Auchus, MD, PhD, PRINCIPAL_INVESTIGATOR, University of Michigan
2027-08