A Study Comparing the Efficacy and Safety of Zanidatamab to Trastuzumab, Each in Combination With Physician's Choice Chemotherapy, for the Treatment of Participants With Metastatic HER2-positive Breast Cancer

Description

The efficacy and safety of zanidatamab in combination with physician's choice of chemotherapy compared with trastuzumab in combination with physician's choice of chemotherapy will be evaluated for the treatment of participants with metastatic HER2-positive breast cancer who have progressed on, or are intolerant to, previous T-DXd treatment.

Conditions

Metastatic HER2-positive Breast Cancer

Study Overview

Study Details

Study overview

The efficacy and safety of zanidatamab in combination with physician's choice of chemotherapy compared with trastuzumab in combination with physician's choice of chemotherapy will be evaluated for the treatment of participants with metastatic HER2-positive breast cancer who have progressed on, or are intolerant to, previous T-DXd treatment.

A Phase 3, Randomized, Open-label, Multicenter, Controlled Study to Evaluate the Efficacy and Safety of Zanidatamab in Combination With Physician's Choice Chemotherapy Compared to Trastuzumab in Combination With Physician's Choice Chemotherapy for the Treatment of Participants With Metastatic HER2-positive Breast Cancer Who Have Progressed on, or Are Intolerant to, Previous Trastuzumab Deruxtecan Treatment

A Study Comparing the Efficacy and Safety of Zanidatamab to Trastuzumab, Each in Combination With Physician's Choice Chemotherapy, for the Treatment of Participants With Metastatic HER2-positive Breast Cancer

Condition
Metastatic HER2-positive Breast Cancer
Intervention / Treatment

-

Contacts and Locations

Tucson

Arizona Oncology Tucson - Wilmot, Tucson, Arizona, United States, 85711

Denver

Rocky Mountain Cancer Centers, Denver, Colorado, United States, 80218

Coon Rapids

Minnesota Oncology Hematology, Coon Rapids, Minnesota, United States, 55433

Asheville

Messino Cancer Center, Asheville, North Carolina, United States, 28806

Cincinnati

Oncology Hematology Care (OHC), Cincinnati, Ohio, United States, 45226

Nashville

Sarah Cannon Research Institute, Nashville, Tennessee, United States, 37203

Fort Worth

Texas Oncology - Fort Worth, Fort Worth, Texas, United States, 76104

Fairfax

Virginia Cancer Specialists, Fairfax, Virginia, United States, 22031

Norfolk

Virginia Oncology Associates, Sentara Health, Norfolk, Virginia, United States, 23502

Roanoke

Blue Ridge Cancer Care, Roanoke, Virginia, United States, 24014

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

    Ages Eligible for Study

    18 Years to

    Sexes Eligible for Study

    ALL

    Accepts Healthy Volunteers

    No

    Collaborators and Investigators

    Jazz Pharmaceuticals,

    Study Record Dates

    2031-11-26