Feasibility of Conducting a Pilot Telehealth Study Assessing the Removal of Filter Ventilation on Smoking Behavior and Biomarkers in Menthol Smokers Switched to Non-menthol Cigarettes

Eligibility Criteria

• * Male or females at least 21 years of age.
• * Smoking menthol cigarettes most of the time (80% of cigarette purchases).
• * Self-report of daily smoking of at least 5 - 25 cigarettes for \>= 3 months by self-report.
• * Carbon monoxide indicative of regular smoking (CO \> 6ppm) prior to randomization.
• * Has regular access to a smartphone or tablet for use with CO device and smartphone, tablet or computer with functioning camera and internet access for telehealth visits and surveys.
• * Unstable health conditions (any significant serious, unstable medical condition including, but not limited to, cardiovascular disease, liver or kidney disease, COPD, bronchitis, within the past 3 months, seizure disorder and cancer (cancer-free \<= years except some skin cancers can be within 5 years), or a COVID-19 positive test or COVID-19 symptoms in the last 30 days or as determined by the licensed medical professional at each site).
• * Purchased alternative nicotine products within the last month
• * Unstable mental health (to be determined by medical history, Patient Health Questionnaire-2 (Prime-MD) and GAD-2 after review by the licensed medical professional at each site).
• * Excessive drinking or problems with drinking or drugs (assessed by PI or licensed medical professional).
• * Currently pregnant, breastfeeding or intending to become pregnant for the duration of the study or unwilling to agree to use adequate protection to avoid pregnancy.
• * Taking exclusionary medications, unstable dosing of medications, or unstable control of symptoms for ongoing medical conditions (medications or conditions that would impact biomarkers or patient safety to be determined by the licensed medical professional).
• * Vital signs outside of the following range:
• * Household member enrolled in the study concurrently.
• * Participated in prior research study during the past three months that would impact baseline smoking or response to study products.
• * Inability to independently read and comprehend the consent form and follow other written study instructions, materials or measures or behavior indicating inability to fully participate in study procedures. Participants are required to complete the protocol at home independently and must show ability to comply with directions.
• * Unstable living environment that would compromise the ability to sequester study products or complete study procedures.