RECRUITING

First-in-human Study of Interferon-y PET Imaging to Assess Response to Immunotherapy

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this clinical trial is to investigate the use of \[89Zr\]Zr-DFO-emapalumab as an IFN-γ PET imaging agent to detect lesions and response to therapy among treatment-naïve non-small cell lung cancer (NSCLC) patients. PET scans following the imaging agent will be completed prior to and about 30 days after starting immunotherapy.

Official Title

IFN-y PET Imaging: Bench to Bedside

Quick Facts

Study Start:2025-09-25
Study Completion:2027-06
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06439914

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. Age 18 years or older
  2. Willing and able to provide informed consent
  3. Able to understand and follow study procedures
  4. Stable medical condition
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Study Contact

Nerissa T Viola, PhD
CONTACT
3135768309
violan@karmanos.org

Principal Investigator

Nerissa T Viola, PhD
PRINCIPAL_INVESTIGATOR
Barbara Ann Karmanos Cancer Institute

Study Locations (Sites)

Karmanos Cancer Institute
Detroit, Michigan, 48201
United States

Collaborators and Investigators

Sponsor: Nerissa T. Viola

  • Nerissa T Viola, PhD, PRINCIPAL_INVESTIGATOR, Barbara Ann Karmanos Cancer Institute

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-09-25
Study Completion Date2027-06

Study Record Updates

Study Start Date2025-09-25
Study Completion Date2027-06

Terms related to this study

Additional Relevant MeSH Terms

  • Non Small Cell Lung Cancer