RECRUITING

SCD Stem Cell Mobilization and Apheresis Using Motixafortide

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Conditions

Sickle Cell DiseaseStem Cell MobilizationApheresisMotixafortide

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study is being done to see if the study drug, motixafortide, is safe in participants with sickle cell disease (SCD). Investigators also want to see if the drug will help the body increase the number of stem cells that can be collected for possible future transplant use. PRIMARY OBJECTIVE * To characterize the safety and tolerability of motixafortide in participants with SCD as determined by the incidence of adverse events (AEs). SECONDARY OBJECTIVES * To characterize the efficacy of a single dose (Part A) or two doses (Part B) of motixafortide for hematopoietic stem cell (HSC) mobilization and apheresis collection in participants with SCD as determined by the yield of CD34+ cells (CD34+ cells/kg). * To measure the mobilization effects of single-day (Part A) or daily dosing (Part B) dosing with motixafortide in the peripheral blood in participants with SCD as determined by peak peripheral blood CD34+ counts * To recommend a phase 2 dosing strategy based on safety, efficacy, and mobilization effects

Official Title

Sickle Cell Disease Stem Cell Mobilization and Apheresis Using Motixafortide

Quick Facts

Study Start:2024-12
Study Completion:2026-07
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06442761

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Participants with severe sickle cell disease (SCD) who are ≥18 years of age and willing to donate autologous hematopoietic stem cells (HSCs) for advancing future gene therapy for SCD after collection of back-up product. Severe SCD, for the purpose of this study, will be defined as participants who are receiving chronic transfusion therapy due to SCD related complications or are eligible for or currently enrolled on an allogeneic transplant protocol.
  2. * Participant must have a documented diagnosis of SCD with documentation of SCD genotype by medical history
  3. * Participants should either have a central line in place or be able to undergo apheresis without the necessity of the insertion of a central venous catheter
  4. * ECOG performance status/Karnofsky score/Lansky score \>80
  5. * White blood cell (WBC) count \>3.0 x 10\^9/L, absolute neutrophil count (ANC) \>1.0 x 10\^9/L, and platelet count \>150 x 10\^9/L, and hemoglobin \>7.0 gm/dL
  6. * Adequate renal function defined as serum/plasma creatinine \< 1.5 mg/dL and an estimated glomerular filtration rate (eGFR) of at least 60 mL/min/1.73 m\^2 based on the CKD-Epi equation or the St. Jude equation.
  7. * Adequate liver function defined as direct bilirubin \< 2.5 times the upper limit of normal range; aspartate aminotransferase (AST) and alanine aminotransferase (ALT) \< 5 times the upper limit of normal range.
  8. * Participant's cardiac function (i.e., ejection fraction \>40%) and pulmonary status (i.e., no evidence of pulmonary hypertension) must be sufficient to undergo apheresis, as assessed by the Principal Investigator and an independent physician evaluating the participant.
  9. * Negative serologic tests for syphilis, hepatitis B and C, HIV, and HTLV-1/II
  10. * Feasible manual or automated exchange transfusion plan to achieve hemoglobin S (HbS) near 30% within one week of mobilization
  11. * Female participants of childbearing age should have a negative serum pregnancy test within one week of beginning motixafortide administration.
  12. * Participants of childbearing potential should agree to use of a highly effective form of contraception during treatment and for at least 1 month after the last dose of motixafortide. Women of childbearing potential must agree to use 2 methods of effective contraception: One barrier method (e.g. diaphragm, or condom or sponge, each of which are to be combined with a spermicide) and one hormonal method, unless she uses a highly effective method. Highly effective methods of contraception include:
  13. * Combined (estrogen and progestogen containing) hormonal contraception associated with inhibition of ovulation: oral, intravaginal, transdermal
  14. * Progestogen-only hormonal contraception associated with inhibition of ovulation: oral, injectable, implantable
  15. * Intrauterine device (IUD)
  16. * Intrauterine hormone-releasing system (IUS)
  17. * Bilateral tubal occlusion
  18. * Vasectomised partner
  19. * Sexual abstinence.
  1. * Emergency room admission or hospitalization in the past 14 days prior to first dose of study drug
  2. * Major surgery in the past 30 days prior to first dose of study drug
  3. * Active and painful splenomegaly or splenomegaly (size greater than upper limit of normal on examination).
  4. * Participant who, by medical history, requires rare donor registry RBC units for transfusion, or is unable to receive routine transfusion. Eligible study participants must have undergone prior work-up for the presence of red cell alloantibodies and confirmation of available compatible blood product support
  5. * Known allergy to or contraindication for motixafortide administration, or medications routinely administered during apheresis
  6. * Participant who has had a prior autologous or allogeneic transplantation, inclusive of gene therapy
  7. * Active viral, bacterial, fungal, or parasitic infection.
  8. * History of cancer, excluding squamous carcinoma of the skin and cervical carcinoma in situ.
  9. * Participant who has received experimental therapy within 4 weeks prior to providing informed consent
  10. * Poorly controlled diabetes mellitus, as assessed by the Investigator
  11. * Concomitant treatment with alternative investigational agent unable to be held for 30 days
  12. * Unwillingness to use a highly effective method of contraception for 1 month after motixafortide
  13. * Pregnancy
  14. * Inability or unwillingness of research participant or legal guardian/ representative to give written informed consent.
  15. * Inability or unwillingness of research participant to hold hydroxyurea for 30 days prior to first dose of study drug

Contacts and Locations

Study Contact

Alexis Leonard, MD
CONTACT
866-278-5833
referralinfo@stjude.org

Principal Investigator

Alexis Leonard, MD
PRINCIPAL_INVESTIGATOR
St. Jude Children's Research Hospital
Akshay Sharma, MBBS, MSc
PRINCIPAL_INVESTIGATOR
St. Jude Children's Research Hospital

Study Locations (Sites)

St. Jude Children's Research Hospital
Memphis, Tennessee, 38105
United States

Collaborators and Investigators

Sponsor: St. Jude Children's Research Hospital

  • Alexis Leonard, MD, PRINCIPAL_INVESTIGATOR, St. Jude Children's Research Hospital
  • Akshay Sharma, MBBS, MSc, PRINCIPAL_INVESTIGATOR, St. Jude Children's Research Hospital

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-12
Study Completion Date2026-07

Study Record Updates

Study Start Date2024-12
Study Completion Date2026-07

Terms related to this study

Keywords Provided by Researchers

  • Stem Cell Mobilization
  • Apheresis
  • Motixafortide

Additional Relevant MeSH Terms

  • Sickle Cell Disease