Transient Receptor Potential Channels

Description

Neurovascular signaling in the skin associated with stimulation of the transient receptor potential (TRP) channels. These channels are stimulated by both temperature and naturally occurring bioactive agents found in mint, chili peppers, garlic, etc. The aim of the study is to examine how topically applied TRP channel agonists including menthol, capsaicin and camphor impact neurovascular responses in the skin.

Conditions

Aging

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Study Overview

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Study Details

Study overview

Neurovascular signaling in the skin associated with stimulation of the transient receptor potential (TRP) channels. These channels are stimulated by both temperature and naturally occurring bioactive agents found in mint, chili peppers, garlic, etc. The aim of the study is to examine how topically applied TRP channel agonists including menthol, capsaicin and camphor impact neurovascular responses in the skin.

Transient Receptor Potential Channels in Human Skin

Transient Receptor Potential Channels

Condition
Aging
Intervention / Treatment

-

Contacts and Locations

University Park

Noll Laboratory, University Park, Pennsylvania, United States, 16802

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * 18-85 years old.
  • * Women will not be pregnant and/or breastfeeding.
  • * Currently pregnant or breastfeeding
  • * Nicotine use (e.g., smoking, chewing tobacco etc.), quantified as more than 100 cigarettes or cigars in a lifetime)
  • * Known skin allergies or current rash, skin disease, disorders of pigmentation
  • * Diabetes
  • * Body mass index \>35kg\*m-2
  • * Using calcium channel blockers
  • * Raynaud's syndrome
  • * Allergy or hypersensitivity to menthol, camphor, capsaicin or adhesive
  • * Regular use (defined as greater than once a week) of topical analgesics that contain menthol, camphor or capsaicin

Ages Eligible for Study

18 Years to 85 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Penn State University,

Lacy Alexander, Ph.D., PRINCIPAL_INVESTIGATOR, Penn State University

Study Record Dates

2026-12-31