Echography-guided Surfactant THERapy (ESTHER) For Preterm Infants With Respiratory Failure

Description

Point-of-care ultrasound (POCUS) is the use of ultrasound by the bedside provider in real time to answer a specific question and guide medical management. POCUS can be used to diagnose the severity of neonatal respiratory distress syndrome (RDS) through a lung ultrasound score. Lung ultrasound scores have also been shown to predict if an infant is treated with an initial dose of surfactant. Therefore, using lung ultrasound scores to guide surfactant therapy for RDS will likely lead to earlier surfactant therapy and may improve short-term respiratory outcomes. This study will test this theory by comparing lung ultrasound score-guided surfactant therapy for premature infants with RDS with our current surfactant administration guidelines.

Conditions

Respiratory Distress Syndrome, Newborn, Pulmonary Surfactants, Intensive Care Units, Neonatal

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Study Overview

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Study Details

Study overview

Point-of-care ultrasound (POCUS) is the use of ultrasound by the bedside provider in real time to answer a specific question and guide medical management. POCUS can be used to diagnose the severity of neonatal respiratory distress syndrome (RDS) through a lung ultrasound score. Lung ultrasound scores have also been shown to predict if an infant is treated with an initial dose of surfactant. Therefore, using lung ultrasound scores to guide surfactant therapy for RDS will likely lead to earlier surfactant therapy and may improve short-term respiratory outcomes. This study will test this theory by comparing lung ultrasound score-guided surfactant therapy for premature infants with RDS with our current surfactant administration guidelines.

Echography-guided Surfactant THERapy (ESTHER) For Preterm Infants With Respiratory Failure

Echography-guided Surfactant THERapy (ESTHER) For Preterm Infants With Respiratory Failure

Condition
Respiratory Distress Syndrome, Newborn
Intervention / Treatment

-

Contacts and Locations

Hartford

Connecticut Children's, Hartford, Connecticut, United States, 06106

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * The infant's parent/legal guardian can understand and willingly sign a written informed consent document for this study
  • * Birth gestational age between 27w0d-36w6d
  • * Diagnosis of respiratory failure secondary to RDS requiring respiratory support with non-invasive positive pressure ventilation
  • * Unable to obtain lung ultrasound between 1-2 hours of life
  • * Infants already intubated or received surfactant before the point of care lung ultrasound
  • * Infants born with congenital cardiac disease, congenital lung disease, or congenital facial/airway malformations
  • * Infants born with chromosomal abnormalities
  • * Infants with APGARs ≤ 5 at 10 minutes of life
  • * Infants requiring cardiopulmonary resuscitation or therapeutic hypothermia in the first 6 hours of life

Ages Eligible for Study

0 Hours to 2 Hours

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Connecticut Children's Medical Center,

Jacob Kelner, PRINCIPAL_INVESTIGATOR, Connecticut Children's

Study Record Dates

2025-05