Effects of THC on Alcohol Consumption and Neural Correlates of Reward

Description

Alcohol and cannabis are often used together such that their effects overlap, but little is known about the neural mechanisms that underlie simultaneous use. High doses of THC have not been well-studied in the laboratory, and it is unclear how high doses of THC may impact alcohol consumption patterns. The proposed study will explore the effects of oral THC (20mg dronabinol) vs. placebo on neural reward, alcohol self-administration and naturalistic co-use patterns.

Conditions

Cannabis Use Disorder

Study Overview

Study Details

Study overview

Alcohol and cannabis are often used together such that their effects overlap, but little is known about the neural mechanisms that underlie simultaneous use. High doses of THC have not been well-studied in the laboratory, and it is unclear how high doses of THC may impact alcohol consumption patterns. The proposed study will explore the effects of oral THC (20mg dronabinol) vs. placebo on neural reward, alcohol self-administration and naturalistic co-use patterns.

Effects of THC on Alcohol Consumption and Neural Correlates of Reward

Effects of THC on Alcohol Consumption and Neural Correlates of Reward

Condition
Cannabis Use Disorder
Intervention / Treatment

-

Contacts and Locations

Aurora

University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States, 80045

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Drink alcohol
  • * Use cannabis
  • * Contact site for additional details
  • * MRI contraindications (implanted metal, weight \> 315 lb, etc.).
  • * Contact site for additional details

Ages Eligible for Study

21 Years to 40 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Colorado, Denver,

Study Record Dates

2026-06-30