OsteoGen Plug vs. Freeze-dried Bone Allograft With Collagen Barrier

Eligibility Criteria

• * Subjects 18 to 75-yrs of age.
• * Subjects with a nonterminal premolar in need of extraction with intention to pursue implant replacement.
• * Proposed treatment site must have intact buccal cortical plates \> 1 mm in thickness (buccal bone dehiscence up to 25% root length is permissible). Apical lesions are acceptable which do not perforate the cortical plate).
• * Proposed treatment site must have intact adjacent natural teeth. (no adjacent edentulous sites or implants).
• * Subjects can provide self-care (oral hygiene) without disabilities requiring assistance with daily oral hygiene measures.
• * Subjects will have read, understood, and signed an institutional review board (IRB) approved Informed Consent Form (ICF).
• * Subjects must be able and willing to follow study procedures and instructions.
• * Subjects with reported allergy or hypersensitivity to any of the products to be used in the study.
• * Subjects with untreated / active periodontal disease.
• * Subjects with vesiculobullous processes or other similar chronic oral lesions / conditions resulting in gingival irritation, discomfort/pain, or erosions.
• * Tobacco/Cannabis users including cigarettes, vape, cigars, or smokeless tobacco.
• * Uncontrolled medical conditions (e.g., diabetes mellitus, hypertension, cancer)
• * Subjects who are lactating or pregnant or planning to become pregnant through their projected study duration.
• * Subjects who would require a tissue supported interim prosthesis i.e. acrylic / valplast RPD (tooth supported interim prostheses i.e. essix retainers are acceptable)
• * Subjects with long-term history of oral bisphosphonates (\> 10 years).
• * Subjects with a history of intravenous bisphosphonates.
• * Subjects taking medications known to affect gingival conditions. (e.g., hyperplasia)
• * Subjects taking corticosteroids or immunosuppressants on a regular basis prior to baseline examination.
• * Subjects taking anticoagulant medications such as warfarin or Plavix or Eliquis who are not medically cleared to hold medication prior to and during procedure.
• * Subjects participating in other clinical studies involving therapeutic intervention (either medical or dental).
• * Subjects, who in the opinion of the investigator, for any reason other than those listed above, will not be able to complete the study per protocol.