RECRUITING

Trial of Precision Medicine in Emergency Departments

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The objectives of this study are to (1) test the feasibility of the clinical implementation of preemptive pharmacogenetic (PGx) testing in the emergency department (ED) and (2) determine if PGx testing (with appropriate decision support) decreases ED return visits and hospitalizations. We will conduct a randomized, controlled, pragmatic clinical trial assessing both the real-world effectiveness as well as implementation outcomes using a targeted PGx testing panel in several UF Health EDs.

Official Title

Trial of Precision Medicine in Emergency Departments

Quick Facts

Study Start:2025-03-18
Study Completion:2027-07-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06448091

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. 1. Adults (18 years or older) presenting to a participating ED
  2. 2. Diagnosis or suspicion of a condition that might be treated by a PGx drug (See Table 3).
  3. 3. Documentation of a prior ED visit within the past 6 months
  1. 1. Patients with prior clinical pharmacogenetic test results within the EHR for genes relevant for this study
  2. 2. Any medical condition that would prohibit the ability to complete the study
  3. 3. Life expectancy less than 6 months

Contacts and Locations

Study Contact

Erica N Elwood, MHA
CONTACT
3522736007
erica.elwood@cop.ufl.edu

Principal Investigator

Julio D Duarte, Pharm.D., Ph.D.
PRINCIPAL_INVESTIGATOR
University of Florida

Study Locations (Sites)

UF Health Emergency Department
Gainesville, Florida, 32610
United States
UF Health Jacksonville Downtown Emergency Department
Jacksonville, Florida, 32209
United States
UF Health Jacksonville North Emergency Department
Jacksonville, Florida, 32218
United States

Collaborators and Investigators

Sponsor: University of Florida

  • Julio D Duarte, Pharm.D., Ph.D., PRINCIPAL_INVESTIGATOR, University of Florida

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-03-18
Study Completion Date2027-07-01

Study Record Updates

Study Start Date2025-03-18
Study Completion Date2027-07-01

Terms related to this study

Additional Relevant MeSH Terms

  • Pharmacogenomic Drug Interaction