Manipulating E-Cigarette Nicotine to Promote Public Health

Description

This clinical trial explores the manipulation of e-cigarette (EC) nicotine to promote public health. Researchers are trying to understand and gather information about how the strength, form, and structure of nicotine in products play a significant role in their potential for addiction and how they might affect health risks. The information gained from this study may allow researchers to understand how these aspects of nicotine influence the potential for addiction, how people puff on ECs, how the body processes nicotine, and any potential harmful effects it might have on health. Exploring these specific characteristics of nicotine may also determine if an EC product standard could help identify optimal nicotine levels for users.

Conditions

Tobacco-Related Carcinoma

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Study Overview

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Study Details

Study overview

This clinical trial explores the manipulation of e-cigarette (EC) nicotine to promote public health. Researchers are trying to understand and gather information about how the strength, form, and structure of nicotine in products play a significant role in their potential for addiction and how they might affect health risks. The information gained from this study may allow researchers to understand how these aspects of nicotine influence the potential for addiction, how people puff on ECs, how the body processes nicotine, and any potential harmful effects it might have on health. Exploring these specific characteristics of nicotine may also determine if an EC product standard could help identify optimal nicotine levels for users.

Manipulating E-Cigarette Nicotine to Promote Public Health

Manipulating E-Cigarette Nicotine to Promote Public Health

Condition
Tobacco-Related Carcinoma
Intervention / Treatment

-

Contacts and Locations

Columbus

Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States, 43210

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Current exclusive young adult EC user for at least the past 3 months (confirmed by cotinine testing strip) between 21-24 years old with no/minimal history of smoking cigarettes (\< 10 cigarettes in entire life)
  • * Current older adult smoker (daily use, ≥ 100 cigarettes in entire life) aged 25-65 with interest in trying an EC
  • * Willing to abstain from all nicotine, tobacco products, and marijuana for at least 12 hours before study visits
  • * Read and speak English
  • * Currently attempting to quit nicotine or tobacco products
  • * Currently pregnant (will be verified with urine pregnancy test), planning to become pregnant, or breastfeeding
  • * Current daily use of other tobacco products other than ECs or cigarettes (use of \> 10 traditional cigars, cigarillos, or filtered cigars in entire life; use of smokeless tobacco products \> 10 times in entire life; or hookah in the last 30 days)
  • * Self-reported diagnosis of lung disease including asthma, cystic fibrosis, or chronic obstructive pulmonary disease
  • * New or unstable cardiovascular disease diagnosed within the past 3 months
  • * Use of medications that are inducers of CYP2A6 enzyme such as rifampicin, dexamethasone, phenobarbital, and other anti-convulsion drugs

Ages Eligible for Study

21 Years to 65 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Ohio State University Comprehensive Cancer Center,

Theodore L Wagener, PRINCIPAL_INVESTIGATOR, Ohio State University Comprehensive Cancer Center

Study Record Dates

2027-05-20