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Safety, Preliminary Effectiveness of BNT327, an Investigational Therapy for Patients With Small-cell Lung Cancer in Combination With Chemotherapy

Description

This is a Phase II, multi-site, open-label, parallel group study in participants with untreated extended-stage small-cell lung cancer (ES-SCLC) (Cohort 1) or small-cell lung cancer (SCLC) which has progressed on first- or second-line treatment (Cohort 2 and Cohort 3). This study will assess the safety, efficacy, and pharmacokinetics (PK) of BNT327.

Conditions

Extensive-stage Small-cell Lung CancerSmall-cell Lung Cancer
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Related Conditions:

Extensive-stage Small-cell Lung CancerSmall-cell Lung Cancer

Study Overview

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Study Details

Study overview

This is a Phase II, multi-site, open-label, parallel group study in participants with untreated extended-stage small-cell lung cancer (ES-SCLC) (Cohort 1) or small-cell lung cancer (SCLC) which has progressed on first- or second-line treatment (Cohort 2 and Cohort 3). This study will assess the safety, efficacy, and pharmacokinetics (PK) of BNT327.

A Phase II, Multi-site, Open-label, Parallel Group Trial of BNT327 in Combination With Chemotherapy for Participants With Untreated Extensive-stage Small-cell Lung Cancer and Participants With Previously Treated Small-cell Lung Cancer

Safety, Preliminary Effectiveness of BNT327, an Investigational Therapy for Patients With Small-cell Lung Cancer in Combination With Chemotherapy

Condition
Extensive-stage Small-cell Lung Cancer
Intervention / Treatment

-

Contacts and Locations

Anchorage

Alaska Oncology and Hematology, LLC, Anchorage, Alaska, United States, 99508

Los Angeles

Valkyrie Clinical Trials, Los Angeles, California, United States, 90067

Clermont

Clermont Oncology Center, Clermont, Florida, United States, 34711

Port Saint Lucie

Hematology Oncology Associates of Treasure Coast, Port Saint Lucie, Florida, United States, 34952

Tallahassee

Tallahassee Memorial Physician Partners - Cancer & Hematology Specialists, Tallahassee, Florida, United States, 32308

Urbana

Carle Foundation Hospital d/b/a Carle Cancer Center, Urbana, Illinois, United States, 61801

Fort Wayne

Fort Wayne Medical Oncology and Hematology, Inc, Fort Wayne, Indiana, United States, 46804

Lexington

University of Kentucky Chandler Medical Center (UKCMC) - Markey Cancer Center (Lucille P. Markey Cancer Center), Lexington, Kentucky, United States, 40536

Minneapolis

Allina Health, Minneapolis, Minnesota, United States, 55407

Hattiesburg

Hattiesburg Clinic - Hattiesburg, Hattiesburg, Mississippi, United States, 39401

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

    Ages Eligible for Study

    18 Years to

    Sexes Eligible for Study

    ALL

    Accepts Healthy Volunteers

    No

    Collaborators and Investigators

    BioNTech SE,

    BioNTech Responsible Person, STUDY_DIRECTOR, BioNTech SE

    Study Record Dates

    2026-08