Androgen Effects on the Reproductive Neuroendocrine Axis

Description

This research study investigates whether male-level exogenous androgens inhibit the reproductive neuroendocrine axis in otherwise healthy (non-PCOS) females.

Conditions

Transgenderism, Reproductive Issues

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Study Overview

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Study Details

Study overview

This research study investigates whether male-level exogenous androgens inhibit the reproductive neuroendocrine axis in otherwise healthy (non-PCOS) females.

Androgen Effects on the Reproductive Neuroendocrine Axis

Androgen Effects on the Reproductive Neuroendocrine Axis

Condition
Transgenderism
Intervention / Treatment

-

Contacts and Locations

San Diego

University of California San Diego, San Diego, California, United States, 92037

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Provision of signed and dated informed consent form
  • * Stated willingness to comply with all study procedures and availability for the duration of the study
  • * Aged 18-35
  • * Plan to initiate testosterone therapy
  • * History of regular menstrual cycles (every 24-35 days) at baseline, before beginning TRT
  • * Pregnant
  • * Incarcerated
  • * Known cognitive impairment or institutionalized
  • * Hemoglobin less than 11 gm/dl at screening evaluation
  • * Weight less than 110 pounds
  • * BMI \<18 or \>35
  • * Current endocrine disease- including untreated thyroid abnormalities, pituitary or adrenal disease, polycystic ovary syndrome, or androgen producing tumor
  • * Current or recent pregnancy within two months of study enrollment
  • * Current or recent breast feeding within two months of study enrollment
  • * Diabetes, or renal, liver, or heart disease
  • * History of oophorectomy or hysterectomy
  • * History of radiation or surgery involving brain structures and/or pelvis/pelvic organs
  • * Currently taking any medications that may affect their reproductive hormones, such as contraceptive medications, androgens, estrogens, progestins, GnRH antagonists, GnRH agonists, insulinomimetics, and metformin.
  • * History of prior testosterone therapy

Ages Eligible for Study

18 Years to 35 Years

Sexes Eligible for Study

FEMALE

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of California, San Diego,

Antoni Duleba, MD, PRINCIPAL_INVESTIGATOR, UC San Diego

Study Record Dates

2028-11-30