RECRUITING

Imaging Speech in Neurotypical Adults and Individuals With Cerebellar Stroke

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this research study is to learn how the brain areas that plan and control movement interact with the areas responsible for hearing and perceiving speech in healthy adults and people who have had cerebellar strokes. The main questions it aims to answer are: 1. What regions of the brain's sensory systems show changes in their activity related to speech? 2. To what extent do these regions help listeners detect and correct speech errors? 3. What is the role of the cerebellum (a part of the brain in the back of the head) in these activities? Participants will be asked to complete several experimental sessions involving behavioral speech and related tests and non-invasive brain imaging using electroencephalography (EEG) and functional magnetic resonance imaging (fMRI).

Official Title

High-resolution Functional Imaging of Speech-induced Sensory Modulation

Quick Facts

Study Start:2025-05-27
Study Completion:2028-07
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06458153

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Age 18-49
  2. * Right-handed
  3. * Native English speaker
  4. * Age 18 or older
  5. * Right-handed
  6. * Native English speaker
  7. * History of cerebellar stroke
  8. * Age 18 or older
  9. * Right-handed
  10. * Native English speaker
  1. * Presence of MRI risk factors: metal and/or electromagnetic devices (e.g., pacemakers, neurostimulators) in the body, previous shrapnel injuries, use of an intrauterine device containing metal, claustrophobia, pregnant or possibly pregnant
  2. * History of neurological / neurodegenerative disease or severe brain injury (e.g., stroke or severe traumatic brain injury)
  3. * Hearing loss, defined by pure tone thresholds \>25 decibels (dB) hearing level (HL) at octave frequencies between 250-8000 Hz
  4. * Clinical diagnosis and/or treatment for schizophrenia or other psychotic disorders
  5. * Clinical diagnosis and/or treatment for neurocognitive disorders (e.g., dementia, delirium)
  6. * Presence of a severe and unmanaged, clinically diagnosed attention disorder
  7. * Clinically diagnosed with or treated for a speech, language, or hearing disorder
  8. * Head circumference greater than 60cm or weight greater than 300 pounds
  9. * History of severe claustrophobia
  10. * Currently pregnant
  11. * Presence of MRI risk factors: metal and/or electromagnetic devices (e.g., pacemakers, neurostimulators) in the body, previous shrapnel injuries, use of an intrauterine device containing metal, claustrophobia, pregnant or possibly pregnant
  12. * History of neurological / neurodegenerative disease or severe brain injury other than stroke
  13. * Hearing loss, defined by pure tone thresholds \>50 dB HL at octave frequencies between 250-4000 Hz
  14. * Clinical diagnosis and/or treatment for schizophrenia or other psychotic disorders
  15. * Clinical diagnosis and/or treatment for neurocognitive disorders (e.g., dementia, delirium)
  16. * Presence of a severe and unmanaged, clinically diagnosed attention disorder
  17. * Head circumference greater than 60cm or weight greater than 300 pounds
  18. * History of severe claustrophobia
  19. * Currently pregnant
  20. * Presence of MRI risk factors: metal and/or electromagnetic devices (e.g., pacemakers, neurostimulators) in the body, previous shrapnel injuries, use of an intrauterine device containing metal, claustrophobia, pregnant or possibly pregnant
  21. * History of neurological / neurodegenerative disease or severe brain injury (e.g., stroke or severe traumatic brain injury)
  22. * Hearing loss, defined by pure tone thresholds \>50 dB HL at octave frequencies between 250-4000 Hz
  23. * Clinical diagnosis and/or treatment for schizophrenia or other psychotic disorders
  24. * Clinical diagnosis and/or treatment for neurocognitive disorders (e.g., dementia, delirium)
  25. * Presence of a severe and unmanaged, clinically diagnosed attention disorder
  26. * Clinically diagnosed with or treated for a speech, language, or hearing disorder
  27. * Head circumference greater than 60cm or weight greater than 300 pounds
  28. * History of severe claustrophobia
  29. * Currently pregnant

Contacts and Locations

Study Contact

Jason W Bohland, Ph.D.
CONTACT
412-383-3416
j.bohland@pitt.edu
Alexander Ocampo, B.A.
CONTACT
amo104@pitt.edu

Principal Investigator

Jason W Bohland, Ph.D.
PRINCIPAL_INVESTIGATOR
University of Pittsburgh

Study Locations (Sites)

University of Pittsburgh
Pittsburgh, Pennsylvania, 15260
United States

Collaborators and Investigators

Sponsor: University of Pittsburgh

  • Jason W Bohland, Ph.D., PRINCIPAL_INVESTIGATOR, University of Pittsburgh

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-05-27
Study Completion Date2028-07

Study Record Updates

Study Start Date2025-05-27
Study Completion Date2028-07

Terms related to this study

Keywords Provided by Researchers

  • fmri
  • speech production
  • cerebellum
  • auditory-motor integration
  • speech motor control
  • neuroimaging

Additional Relevant MeSH Terms

  • Stroke
  • Cerebellum