Packed Red Blood Cell Transfusion During Cardiac Arrest

Description

The purpose of this pilot interventional study is to collect preliminary data on administering packed red blood cell (PRBC) during cardiac arrest (CA). The primary objective is to assess the feasibility of PRBC transfusion during cardiac CA to help optimize the methods required to augment cerebral and other vital organ oxygen delivery during cardiopulmonary resuscitation (CPR). The secondary objectives are to assess the effect of PRBC transfusion during prolonged cardiac arrests on cerebral oxygenation, end tidal carbon dioxide (ETCO2), return of spontaneous circulation (ROSC), survival to discharge, biomarkers of neural injury and inflammation, and neurological outcomes at hospital discharge, 30 days post-CA, and 90 days post-CA.

Conditions

Cardiac Arrest

Talk to us

Study Overview

On this page

Study Details

Study overview

The purpose of this pilot interventional study is to collect preliminary data on administering packed red blood cell (PRBC) during cardiac arrest (CA). The primary objective is to assess the feasibility of PRBC transfusion during cardiac CA to help optimize the methods required to augment cerebral and other vital organ oxygen delivery during cardiopulmonary resuscitation (CPR). The secondary objectives are to assess the effect of PRBC transfusion during prolonged cardiac arrests on cerebral oxygenation, end tidal carbon dioxide (ETCO2), return of spontaneous circulation (ROSC), survival to discharge, biomarkers of neural injury and inflammation, and neurological outcomes at hospital discharge, 30 days post-CA, and 90 days post-CA.

A Single-center, Randomized, Placebo Controlled Pilot Study of Packed Red Blood Cell Transfusion During Prolonged Adult In-hospital Cardiac Arrest

Packed Red Blood Cell Transfusion During Cardiac Arrest

Condition
Cardiac Arrest
Intervention / Treatment

-

Contacts and Locations

New York

NYU Langone Health, New York, New York, United States, 10016

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Adult patients, age ≥18 and \<85 years
  • * Experience prolonged, non-trauma-related in-hospital cardiac arrest, defined by cessation of heartbeat and respiration requiring CPR for at least 10 minutes
  • * Age \<18 years old
  • * Age \> 85 years old
  • * Patients with DNR/DNI orders (Do Not Resuscitate/Do Not Intubate)
  • * Patients admitted to the hospital with a cardiac arrest arising from trauma
  • * Patients who achieve return of spontaneous circulation within 10 minutes of CPR
  • * Inability to start study product administration within 20 minutes of cardiac arrest onset
  • * Prisoners
  • * Women who are known to be pregnant
  • * Patients with a history of RBC antibodies or positive antibody screen prior to enrollment in the study, unless previously cross-matched units are available for transfusion.
  • * Patients with ultrasound evidence of right ventricular dilatation at time of CA
  • * Patients with known prior objection to receipt of blood products.
  • * Patients for whom administration of additional fluid volume is contraindicated (as determined by physician responsible for care)
  • * Physician objection based on concern that intervention would interfere with patient care plan

Ages Eligible for Study

18 Years to 85 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

NYU Langone Health,

Sam Parnia, MD, PRINCIPAL_INVESTIGATOR, NYU Langone Health

Study Record Dates

2026-04-01