RECRUITING

Non-interventional Study of Patients With Transthyretin (ATTR) Amyloidosis

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The MaesTTRo study aims to enroll a global cohort of patients with transthyretin (ATTR) amyloidosis to longitudinally observe the natural course of the disease and describe real-world treatment patterns and outcomes. In addition, information on the effectiveness of ATTR amyloidosis treatments, including eplontersen, which is a ligand-conjugated antisense oligonucleotide gene silencing treatment targeting activity against both the mutant and wild-type TTR protein, will be collected.

Official Title

A Non-interventional, Prospective, Multi-country Study Collecting Real-world Data on the Characteristics, Treatment Patterns, and Outcomes of Patients With Transthyretin (ATTR) Amyloidosis

Quick Facts

Study Start:2024-06-25
Study Completion:2031-06-27
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06465810

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 130 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Patient willing and able to provide written informed consent to participate in the study
  2. * Confirmed diagnosis of amyloid transthyretin (ATTR) amyloidosis
  3. * Aged ≥18 years at the time of signing the informed consent
  4. * Patient willing and able to participate in collection of electronic patient reported outcomes (PROs)
  1. * Concurrent participation in any interventional trial for ATTR amyloidosis
  2. * Involvement in the planning and/or conduct of the current study
  3. * Patients with evidence of primary or light chain amyloidosis (AL) or serum protein A amyloidosis (AA)
  4. * Asymptomatic patients with ATTR amyloidosis and asymptomatic ATTR mutation carriers

Contacts and Locations

Study Contact

AstraZeneca Clinical Study Information Center
CONTACT
1-877-240-9479
information.center@astrazeneca.com

Study Locations (Sites)

Research Site
Los Angeles, California, 90095
United States
Research Site
San Francisco, California, 94025
United States
Research Site
San Francisco, California, 94143
United States
Research Site
Washington, District of Columbia, 20010
United States
Research Site
Indianapolis, Indiana, 06200
United States
Research Site
Boston, Massachusetts, 02111
United States
Research Site
Saint Louis, Missouri, 63110
United States
Research Site
New Brunswick, New Jersey, 08901
United States
Research Site
Manhasset, New York, 11030
United States
Research Site
Germantown, Tennessee, 38138
United States
Research Site
Dallas, Texas, 75246
United States
Research Site
Seattle, Washington, 98915
United States

Collaborators and Investigators

Sponsor: AstraZeneca

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-06-25
Study Completion Date2031-06-27

Study Record Updates

Study Start Date2024-06-25
Study Completion Date2031-06-27

Terms related to this study

Keywords Provided by Researchers

  • Amyloidosis
  • Transthyretin
  • Hereditary transthyretin-mediated (hATTR) amyloidosis
  • hATTR amyloidosis
  • Hereditary ATTR amyloidosis
  • Wild-type amyloidosis
  • wtATTR amyloidosis
  • ATTRv amyloidosis
  • ATTRwt amyloidosis
  • Polyneuropathy
  • Familial amyloid polyneuropathies
  • ATTR
  • Transthyretin amyloidosis
  • TTR-mediated amyloidosis
  • Polyneuropathies
  • Amyloid neuropathies
  • Amyloid neuropathies, familial
  • Amyloidosis, familial
  • Eplontersen
  • Non-interventional
  • Observational
  • Real-world

Additional Relevant MeSH Terms

  • Transthyretin Amyloidosis
  • ATTR-CM
  • ATTRv-PN
  • ATTR
  • ATTR-Mixed
  • hATTR