Effects of Drugs on Stress Memories

Description

There is evidence that cannabinoids, including delta-9-tetrahydrocannabinol (THC), reduce responses to acute stress and fear-related stimuli, but few studies have examined the effects of THC on memories of stressful experiences. The researchers hypothesize that THC will attenuate behavioral and physiological responses to negative valence stimuli, including memories of aversive experiences.

Conditions

Delta-9-tetrahydrocannabinol (THC), Stress

Study Overview

Study Details

Study overview

There is evidence that cannabinoids, including delta-9-tetrahydrocannabinol (THC), reduce responses to acute stress and fear-related stimuli, but few studies have examined the effects of THC on memories of stressful experiences. The researchers hypothesize that THC will attenuate behavioral and physiological responses to negative valence stimuli, including memories of aversive experiences.

Effects of Drugs on Stress Memories

Effects of Drugs on Stress Memories

Condition
Delta-9-tetrahydrocannabinol (THC)
Intervention / Treatment

-

Contacts and Locations

Chicago

University of Chicago, Chicago, Illinois, United States, 60637

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * 18-35 y/o
  • * BMI 19-29 kg/m2
  • * some prior experience with cannabis (used at least 4 times, no adverse experiences, and current use no more than once a week)
  • * Current severe substance use disorder
  • * history of psychosis or mania
  • * Lack of English fluency
  • * Current DSM IV Axis I disorder
  • * Abnormal EKG
  • * Daily use of medications outside of contraception,
  • * Women who are pregnant or trying to become pregnant

Ages Eligible for Study

18 Years to 35 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Chicago,

Harriet de Wit, PRINCIPAL_INVESTIGATOR, University of Chicago

Study Record Dates

2026-07