OsciPulse D-dimer Pilot Trial

Eligibility Criteria

• 1. Adult aged ≥ 18 years old
• 2. Admitted to the Neuro Intensive Care Unit or Intermediate Neuro Care Unit with a diagnosis of ischemic stroke
• 3. Last known normal \< 24 hours.
• 4. NIH stroke score ≥5
• 5. Weakness in at least one leg (≥ 1 point on the NIHSS lower extremity motor scores)
• 6. Prescribed mechanical therapy for DVT prophylaxis.
• 1. Inability or contraindication to applying IPC to both legs such as:
• * Evidence of acute bone fracture in lower extremities
• * Acute burns in the lower extremities, lacerations, ulcers, active skin infection or dermatitis, in the lower extremities at the site of IPC placement
• * Acute ischemia or severe peripheral vascular disease in the lower extremities as evidenced by cyanotic, cool, pulselessness.
• * Amputated foot or leg on one or two sides
• * Compartment syndrome (acute injury causing swelling and ischemic injury)
• * Severe lower extremity edema (+4 edema as documented by clinical team)
• * Acute deep vein thrombosis 2. Subjects who received thrombolytic therapy (e.g. Alteplase or Tenecteplase) for their stroke 3. Known pregnancy or within 6 weeks of postpartum period. 4. Limitation of life support, life expectancy \< 7 days, or in hospice care 5. A head-unit is unavailable within 24 hours of last known normal. 6. At the discretion of the attending physician and / or clinical team, the subject's participation in the study is believed not to be in the best interest of the subject.