Evaluation of the Pathobiology of CALR-mutated MPN Cells

Description

The purpose of this study is to understand why there is a greater risk of thrombosis in patients who have the JAK2 mutation as compared to those with CALR mutations.

Conditions

Myeloproliferative Neoplasm

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Study Overview

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Study Details

Study overview

The purpose of this study is to understand why there is a greater risk of thrombosis in patients who have the JAK2 mutation as compared to those with CALR mutations.

Evaluation of the Pathobiology of CALR-mutated MPN Cells

Evaluation of the Pathobiology of CALR-mutated MPN Cells

Condition
Myeloproliferative Neoplasm
Intervention / Treatment

-

Contacts and Locations

Charlotte

Atrium Health Levine Cancer, Charlotte, North Carolina, United States, 28204

Winston-Salem

Wake Forest Baptist Comprehensive Cancer Center, Winston-Salem, North Carolina, United States, 27157

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Written (or electronic) informed consent and HIPAA authorization for release of personal health information by participant or his/her legally authorized representative (LAR).
  • * Age ≥ 18 years at the time of enrollment
  • * Diagnosis of myeloproliferative neoplasm (MPN) according to 2022 World Health Organization classification of MDS/MPNs
  • * CALR-positive genetic mutation

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Wake Forest University Health Sciences,

Aleksander Chojecki, MD, PRINCIPAL_INVESTIGATOR, Atrium Health Levine Cancer

Study Record Dates

2026-02