RECRUITING

Blood Changes After Exercise in Restless Legs Syndrome

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this clinical trial is to learn how exercise changes molecules in the blood in people with restless legs syndrome (RLS) to better understand the cause(s) of RLS. The main questions the investigators aim to answer are: How does long-term exercise change proteins in the blood? How does a single exercise session change proteins in the blood? The investigators will compare long-term exercise to no exercise to see if the changes in proteins are specific to exercise. Participants will complete an exercise test and provide blood samples before and after the exercise test. Participants will be randomized (like the flip of a coin) in to either the exercise or no-exercise group for 12 weeks and then complete the exercise test and blood samples again at the end.

Official Title

Proteomic Response to Exercise in Adults With Restless Legs Syndrome

Quick Facts

Study Start:2024-10-21
Study Completion:2026-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06481176

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * age 18 years or older;
  2. * diagnosis of RLS;
  3. * presence of moderate-to-severe RLS (IRLS score\>15);
  4. * currently untreated RLS;
  5. * being non-active defined as not engaging in regular activity (30 minutes accumulated per day) on more than 2 days of the week during the previous six months;
  6. * ability to walk without assistance (does not use a cane/walker/wheelchair for mobility;
  7. * willing to complete outcome measures and complete the exercise program
  1. * present with a condition that can mimic RLS or cause secondary RLS (e.g., iron deficiency anemia, radiculopathy, peripheral edema, peripheral neuropathy, diabetes);
  2. * are at moderate or high risk for undertaking strenuous or maximal exercise

Contacts and Locations

Study Contact

Katie Cederberg, PhD
CONTACT
(650) 725-6517
kcederb@stanford.edu

Principal Investigator

Emmanuel Mignot, MD, PhD
PRINCIPAL_INVESTIGATOR
Stanford University

Study Locations (Sites)

Stanford University
Stanford, California, 94304
United States

Collaborators and Investigators

Sponsor: Stanford University

  • Emmanuel Mignot, MD, PhD, PRINCIPAL_INVESTIGATOR, Stanford University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-10-21
Study Completion Date2026-12

Study Record Updates

Study Start Date2024-10-21
Study Completion Date2026-12

Terms related to this study

Keywords Provided by Researchers

  • Exercise
  • Proteomics

Additional Relevant MeSH Terms

  • Restless Legs Syndrome