RECRUITING

Locomotion Adaptation Deficits in Older Adults With Mild Cognitive Impairment and Alzheimers Disease

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Conditions

Alzheimers DiseaseMild Cognitive Impairmentwalking functiongait disturbancesgait variabilitylocomotor adaptation

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

In people with Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD), reduced capacity for locomotor adaptation is a fundamental but poorly understood mechanism that can be a sensitive biomarker of cognitive-motor impairments. It is also an important therapeutic target for exercise-based interventions to improve walking function. The overall goal of this study is to understand the effects of MCI and AD on locomotor adaptation and walking function.

Official Title

Locomotion Adaptation Deficits in Older Adults With Mild Cognitive Impairment and Alzheimers Disease

Quick Facts

Study Start:2025-03-01
Study Completion:2026-09-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06484244

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:50 Years to 90 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * AD and MCI will be defined through formal diagnosis provided by a board-certified Neurologist. Amnestic MCI will be defined using the AD Neuroimaging Initiative (ADNI) criteria. All MCI participants in ADNI are required to have an amnestic subtype defined as:
  2. * Subjective memory concern or a memory problem noted by their partner
  3. * Abnormal memory function documented by a specified education adjusted cutoff score on the delayed paragraph recall of the Anna Thompson story of the Logical Memory subtest from the Wechsler Memory Scale-Revised
  4. * Mini-Mental State Exam (MMSE) score between 20 and 26 (inclusive). Exceptions may be made for subjects with less than 8 years of education at the discretion of the PI. (iv) Single or multi-domain amnestic MCI (both subtypes are at high risk for progression to AD)
  5. * Clinical Dementia Rating (CDR) = 0.5 (Memory Box score must be at least 0.5)
  6. * General functional performance sufficiently preserved
  7. * Evidence of impaired executive function based on Montreal Cognitive Assessment (MoCA) score 13-17
  8. * Able to walk 10 or more feet without an assistive device
  9. * Completed six grades of education or has a good work history (sufficient to exclude intellectual disabilities)
  10. * Not hospitalized within the last 60 days
  1. * Acute medical illness requiring hospitalization
  2. * Uncontrolled congestive heart failure
  3. * History of stroke
  4. * Inability to perform study procedures
  5. * Medical or physical conditions that would preclude participation or walking (e.g., severe arthritis or mobility problems, uncontrolled hypertension or diabetes, renal failure, history of angina with activity)
  6. * On medications that could adversely affect cognition, eg: antipsychotics, opioids, stimulants, chemotherapy, anti-parkinsonian drugs (eg Levodopa), neurologic prescriptions to treat Multiple sclerosis and/or Parkinson's
  7. * Psychotic disorders
  8. * Confounding neurologic conditions (e.g., active central nervous system (CNS) opportunistic infections, seizure disorders, head injury with loss of consciousness \>30 minutes, intracranial neoplasms, stroke with neurological or neuropsychiatric sequelae)
  9. * Substance Use Disorder, Major Depressive and Generalized Anxiety Disorders within six months of evaluation

Contacts and Locations

Study Contact

Trisha Kesar, PT, PhD
CONTACT
(404) 712-5803
tkesar@emory.edu

Principal Investigator

Trisha Kesar, PT, PhD
PRINCIPAL_INVESTIGATOR
Emory University

Study Locations (Sites)

Emory Rehabilitation Hospital
Atlanta, Georgia, 30322
United States

Collaborators and Investigators

Sponsor: Emory University

  • Trisha Kesar, PT, PhD, PRINCIPAL_INVESTIGATOR, Emory University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2025-03-01
Study Completion Date2026-09-01

Study Record Updates

Study Start Date2025-03-01
Study Completion Date2026-09-01

Terms related to this study

Keywords Provided by Researchers

  • walking function
  • gait disturbances
  • gait variability
  • locomotor adaptation

Additional Relevant MeSH Terms

  • Alzheimers Disease
  • Mild Cognitive Impairment