Preoperative Use of Pantoprazole for Prevention of Post Operative Nausea and Vomiting in Gynecologic Surgery

Description

The goal of this clinical trial is to see if pantoprazole (a proton pump inhibitor used for acid reflux/heart burn) can reduce nausea and vomiting after gynecologic surgery in women between the ages of 18 and 79. Researchers will compare a placebo to the active medication. Participants will be asked to take three pills around their surgery, two taken before and one taken the night after.

Conditions

Postoperative Nausea and Vomiting

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Study Overview

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Study Details

Study overview

The goal of this clinical trial is to see if pantoprazole (a proton pump inhibitor used for acid reflux/heart burn) can reduce nausea and vomiting after gynecologic surgery in women between the ages of 18 and 79. Researchers will compare a placebo to the active medication. Participants will be asked to take three pills around their surgery, two taken before and one taken the night after.

Preoperative Use of Pantoprazole for Prevention of Post Operative Nausea and Vomiting in Gynecologic Surgery

Preoperative Use of Pantoprazole for Prevention of Post Operative Nausea and Vomiting in Gynecologic Surgery

Condition
Postoperative Nausea and Vomiting
Intervention / Treatment

-

Contacts and Locations

Portsmouth

Naval Medical Center Portsmouth, Portsmouth, Virginia, United States, 23708

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Undergoing elective gynecological surgery by either an open abdominal or minimally invasive approach (to include both endoscopic and vaginal). Procedure must be performed under general anesthesia.
  • * Pregnant,
  • * Patients with gastrointestinal disease requiring ongoing medical management.
  • * Prior gastrointestinal surgery with the exception of diagnostic procedures, appendectomy and cholecystectomy.
  • * Patients with a history of H2 receptor blocker use, proton pump inhibitor use or other GERD specific therapy within 30 days of surgery.
  • * Any patient identified by their surgical care team as having a history of PONV warranting additional perioperative prophylaxis.
  • * Known r suspected malignancy
  • * Lactose intolerance

Ages Eligible for Study

18 Years to 79 Years

Sexes Eligible for Study

FEMALE

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

United States Naval Medical Center, Portsmouth,

Study Record Dates

2025-03