Motivation for IV Alcohol Self-Administration in Humans

Eligibility Criteria

• 1. Be between the ages of 21 and 65
• 2. Have self-reported alcohol use in the past 30 days
• 3. Meet current (i.e., past 12 months) DSM-5 diagnostic criteria for alcohol use disorder mild-to-severe
• 1. Currently be treatment seeking, in treatment for alcohol use, or have a history of treatment in the 30 days prior to consent
• 2. Have current (last 12 months) DSM-5 diagnosis of substance use disorder for any psychoactive substances other than alcohol and nicotine
• 3. Have a lifetime DSM-5 diagnosis of schizophrenia, bipolar disorder, or any other psychotic disorder
• 4. Have current suicidal ideation or lifetime history of suicide attempt as reported on the Columbia-Suicide Severity Rating Scale (C-SSRS)
• 5. Have a positive urine screen for drugs other than cannabis
• 6. Be pregnant, nursing, or planning to become pregnant while taking part in the study; and must agree to one of the following methods of birth control (if female), unless she or partner are surgically sterile:
• * Oral contraceptives
• * Contraceptive sponge
• * Patch
• * Double barrier
• * Intrauterine contraceptive device
• * Etonogestrel implant
• * Medroxyprogesterone acetate contraceptive injection
• * Hormonal vaginal contraceptive ring
• * Complete abstinence from sexual intercourse
• 7. Have clinically significant abnormalities identified in the physical exam that may interfere with safe study participation (e.g. unstable cardiac, renal, or liver disease; diabetes; uncontrolled hypertension; or HIV)
• 8. Exceed Grade 2 laboratory abnormalities, based on FDA Guidance Document "Toxicity Grading Scale for Healthy Adult and Adolescent Volunteers Enrolled in Preventive Vaccine Clinical Trials"
• 9. Currently use any medications known to interact with alcohol, including: antidepressants, anticonvulsants, opioids, benzodiazepines, medications for diabetes, and medications that affect alcohol metabolism
• 10. Have an intense fear of needles or have had adverse reactions to needle puncture
• 11. Have any other circumstances that, in the opinion of the investigators, would not be a good fit for study participation
• 1. Have a BrAC \> 0.000 g/dl
• 2. Have clinically significant alcohol withdrawal symptoms as indicated by a score ≥ 10 on the Clinical Institute Withdrawal Assessment for Alcohol-Revised (CIWA-R)
• 3. Exceed Grade 2 clinical vital sign abnormalities, based on FDA Guidance Document "Toxicity Grading Scale for Healthy Adult and Adolescent Volunteers Enrolled in Preventive Vaccine Clinical Trials"