Cognition, Flavonoids, Exercise, Gut Microbiome

Description

This NIH project will examine the effects of routine flavonoid-rich blueberry intake (12-weeks), combined with or in the absence of regular moderate exercise, on cognitive function in a clinical population of older participants identified as experiencing age-related cognitive changes. This project's hypothesis is that the combination of flavonoid-rich diet and routine physical activity may potentiate cognitive benefits and reduce cognitive decline in an aging population, via mechanisms mediated by the gut microbiome.

Conditions

Cognitive Decline, Mild

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Study Overview

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Study Details

Study overview

This NIH project will examine the effects of routine flavonoid-rich blueberry intake (12-weeks), combined with or in the absence of regular moderate exercise, on cognitive function in a clinical population of older participants identified as experiencing age-related cognitive changes. This project's hypothesis is that the combination of flavonoid-rich diet and routine physical activity may potentiate cognitive benefits and reduce cognitive decline in an aging population, via mechanisms mediated by the gut microbiome.

Age-related Cognitive Changes: Effects of Combined Flavonoid Intake and Physical Exertion Mediated by the Gut Microbiome

Cognition, Flavonoids, Exercise, Gut Microbiome

Condition
Cognitive Decline, Mild
Intervention / Treatment

-

Contacts and Locations

Kannapolis

Appalachian State University Human Performance Lab, North Carolina Research Campus, Kannapolis, North Carolina, United States, 28081

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Score on the Montreal Cognitive Assessment (MoCA test) of 24.1-25.2 that indicates mild cognitive decline. The MoCA test score ranges from 0 to 30, with higher scores from 26 to 30 considered normal.
  • * Healthy, non-smoking male or female participants 65 to 85 years of age.
  • * Capable of engaging in a supervised 12-week exercise training program (brisk walking or stretching).
  • * Physically inactive (defined as less than 150 min/week moderate or less than 75 minutes vigorous aerobic and/or resistance exercise during the past 4 weeks).
  • * Willingness to be randomized to one of four groups.
  • * Willingness to provide blood, urine, and fecal samples (3 each),
  • * Willingness to avoid blueberry intake during the 12-weeks study (other than what is provided through the study).
  • * Willingness to maintain current diet and physical activity patterns during the study (other than what is prescribed as a part of the study), and make no formal attempts to lose or gain body weight.
  • * Willingness to be a participant in this study only and not enter any other studies.
  • * Allergy to blueberries.
  • * Diagnosis of Type I or Type 2 diabetes.
  • * Chronic cardiovascular, metabolic, or renal condition that is uncontrolled (controlled defined as stable for 6 months or more).
  • * History of signs or symptoms during rest or physical activity such as chest discomfort, unreasonable breathlessness, dizziness, fainting, or blackouts.
  • * Use of any prescription or over-the-counter drug intended to support cognition or with known cognitive side effects.
  • * Any other concurrent condition or use of medications or supplements which, in the opinion of the study clinician would preclude participation in this study.
  • * Diagnosis of dementia.

Ages Eligible for Study

65 Years to 85 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Appalachian State University,

David C Nieman, DrPH, PRINCIPAL_INVESTIGATOR, Appalachian State Univ

Study Record Dates

2028-12-31