RECRUITING

Impact of Obicetrapib and Obicetrapib Plus Repatha on Lp(a) Levels

Conditions

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this open label 16 week trial is to evaluate Lp(a) levels for patients with elevated Lp(a) being treated with obicetrapib and obiceptrapib/evolocumab Patients will: Have baseline Lp(a) tested at randomization Take 10mg/dL obiceptrapib daily for 8 weeks and have Lp(a) tested at Week 8 Take 10 mg/dL obicetrapib daily/evolocumab 140 every other week for 8 weeks and have Lp(a) retested at Week 16

Official Title

A Phase 2 Study to Evaluate the Effect of Obicetrapib Alone and in Combination With Evolocumab (Repatha®) on Lipoprotein (a) in Patients With Mild Dyslipidemia: The VINCENT Study

Quick Facts

Study Start:2024-11
Study Completion:2025-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT06496243

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 75 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Lp(a) \>50 mg/dL
  2. * LDL-C \>70 mg/dL
  3. * TG \< 400mg/dL
  1. * HbA1c\>=10 or FPG \>=270 mg/dL
  2. * CV events within 3 months of screen

Contacts and Locations

Study Contact

Ashley Walker
CONTACT
919 641 5724
ashley.walker@newamsterdampharma.com

Study Locations (Sites)

UPenn
Philadelphia, Pennsylvania, 19104
United States

Collaborators and Investigators

Sponsor: NewAmsterdam Pharma

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-11
Study Completion Date2025-12

Study Record Updates

Study Start Date2024-11
Study Completion Date2025-12

Terms related to this study

Additional Relevant MeSH Terms

  • Dyslipidemias