Mifepristone vs Misoprostol

Description

The Investigator team hypothesizes that in a randomized trial comparing mifepristone-alone or misoprostol-alone for cervical preparation for procedural abortions at 12 to 16 weeks in hospital-based care, the proportion of patients who achieve successful cervical dilation will be different between the study groups.

Conditions

Cervical Preparation

Study Overview

Study Details

Study overview

The Investigator team hypothesizes that in a randomized trial comparing mifepristone-alone or misoprostol-alone for cervical preparation for procedural abortions at 12 to 16 weeks in hospital-based care, the proportion of patients who achieve successful cervical dilation will be different between the study groups.

Mifepristone Versus Misoprostol for Cervical Preparation Prior to Procedural Abortion at 12 to 16 Weeks' Gestation in an Academic Medical Center: a Randomized Controlled Pilot Trial

Mifepristone vs Misoprostol

Condition
Cervical Preparation
Intervention / Treatment

-

Contacts and Locations

Bronx

Montefiore Medical Center, Bronx, New York, United States, 10467

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * English or Spanish-speaking
  • * Capacity to consent
  • * Seeking induced abortion of a singleton pregnancy
  • * Between 12 weeks, 0 days and 16 weeks, 6 days (based on age at day of surgery)
  • * History of more than one prior Cesarean delivery
  • * Sonographic evidence of placenta previa
  • * Sonographic concern for morbidly adherent placenta
  • * Prior obstetric hemorrhage requiring transfusion
  • * Obstructive cervical or lower uterine segment fibroid
  • * Current therapeutic anticoagulation use
  • * Cerclage in situ
  • * History of more than one prior cervical excisional procedure
  • * BMI greater than 45 kg/m\^2

Ages Eligible for Study

18 Years to 45 Years

Sexes Eligible for Study

FEMALE

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Montefiore Medical Center,

Antoinette Danvers, MD, MSCR, MBA, PRINCIPAL_INVESTIGATOR, Montefiore Medical Center

Study Record Dates

2026-10