Hippocampal Network Changes Following Mindfulness Training in Tobacco Vaping Adolescents in an Open-label, Pilot Study

Description

The purpose of this translational bench-to-bedside study is to examine the neurobiological effects of an evidence-based technology-delivered mindfulness training (MT) program on vaping-related rsFC alterations in hippocampal networks and testing whether changes in rsFC ((Delta)rsFC) in these networks predict reduction in tobacco vaping behaviors in adolescents. The study also aims to test the accessibility and feasibility of using this mindfulness-based stress reduction (MBSR) platform as an implementation for widespread MT in adolescents....

Conditions

Vaping Teens, Healthy Volunteers

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Study Overview

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Study Details

Study overview

The purpose of this translational bench-to-bedside study is to examine the neurobiological effects of an evidence-based technology-delivered mindfulness training (MT) program on vaping-related rsFC alterations in hippocampal networks and testing whether changes in rsFC ((Delta)rsFC) in these networks predict reduction in tobacco vaping behaviors in adolescents. The study also aims to test the accessibility and feasibility of using this mindfulness-based stress reduction (MBSR) platform as an implementation for widespread MT in adolescents....

Hippocampal Network Changes Following Mindfulness Training in Tobacco Vaping Adolescents

Hippocampal Network Changes Following Mindfulness Training in Tobacco Vaping Adolescents in an Open-label, Pilot Study

Condition
Vaping Teens
Intervention / Treatment

-

Contacts and Locations

Baltimore

National Institute on Drug Abuse, Baltimore, Maryland, United States, 21224

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. For adolescents aged 17 and under, parental/guardian informed consent to participate in the study
  • 2. English language fluency
  • 3. Males and females; Age 13-18 enrolled in grades 9-12.
  • 4. No MRI contraindications
  • 5. No evidence of current psychosis, mania, or significant suicidality
  • 6. If on medication for depression, anxiety or ADHD, dose has been stable for 3 months
  • 7. No DSM-5 diagnosis of moderate or severe SUD related to a psychoactive substance, including tobacco, in the past year
  • 8. Access to necessary resources for participating in a technology-based intervention, which includes smartphone ownership for this study
  • 9. No use of nicotine more than 5 times in their life, and none at all in the last 30 days prior to enrollment.
  • 1. For adolescents aged 17 and under, parental/guardian informed consent to participate in the study
  • 2. English language fluency
  • 3. Males and females; Age 13-18 enrolled in grades 9-12.
  • 4. No MRI contraindications
  • 5. No evidence of current psychosis, mania, or significant suicidality
  • 6. If on medication for depression, anxiety or ADHD, dose has been stable for 3 months
  • 7. No DSM-5 diagnosis of moderate or severe SUD related to another psychoactive substance (other than tobacco) in the past year
  • 8. Vape a nicotine containing product at least 10 days in the past 30 days
  • 9. Access to necessary resources for participating in a technology-based intervention, which includes smartphone ownership for this study
  • 1. Chronic medical conditions associated with cerebral blood flow abnormalities per PI/MAI determination after review of the medical history.
  • 2. Neurological conditions that may interfere with MRI data quality per PI/MAI determination after review of the medical history.
  • 3. Neurodevelopmental disorders that are likely to significantly affect data in the judgment of the MAI/PI
  • 4. Non-penetrating traumatic brain injury with loss of consciousness \> 30 minutes or significant sequalae persisting longer than 2 weeks or any penetrating traumatic brain injury.
  • 5. Changing dose of psychotropic medication in past 3 months
  • 6. Current regular meditation or yoga practice averaging \>10 min/day for \>2 days per week
  • 7. Pregnancy, self-report upon protocol entry, but by urine test prior to MRI scan.

Ages Eligible for Study

13 Years to 18 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

National Institute on Drug Abuse (NIDA),

Betty Jo Salmeron, M.D., PRINCIPAL_INVESTIGATOR, National Institute on Drug Abuse (NIDA)

Study Record Dates

2026-06-05