Low-Dose Ketamine Infusion During Burn Wound Care

Description

The current standard of care (SOC) (i.e. fentanyl and midazolam) offers limited efficacy for preventing or relieving pain. Ketamine infusions may provide the benefits of analgesia, minimize adverse events, and reduce opioid use. The purpose of this study is to determine if adding a low dose ketamine infusion during wound care will safely provide pain relief for patients with burn injury.

Conditions

Burn, Pain, Dissociation, Opioid

Study Overview

Study Details

Study overview

The current standard of care (SOC) (i.e. fentanyl and midazolam) offers limited efficacy for preventing or relieving pain. Ketamine infusions may provide the benefits of analgesia, minimize adverse events, and reduce opioid use. The purpose of this study is to determine if adding a low dose ketamine infusion during wound care will safely provide pain relief for patients with burn injury.

A Randomized, Placebo-Controlled, Double-Blind Evaluation of Low-Dose Ketamine Infusion During Burn Wound Care Procedures to Improve Pain Intensity and Reduce Opioid Consumption

Low-Dose Ketamine Infusion During Burn Wound Care

Condition
Burn
Intervention / Treatment

-

Contacts and Locations

Memphis

Regional One Health, Memphis, Tennessee, United States, 38103

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Admitted to burn service with thermal injury
  • * unable/unwilling to consent within 72 hours
  • * unable to report NRS
  • * known contraindication to ketamine
  • * \< than 18 years of age
  • * pregnant
  • * incarcerated
  • * TBSA over 50 %

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Tennessee,

Study Record Dates

2025-12