Multidimensional Predictive Modeling to Understand Mechanisms of Exercise Response Heterogeneity in Older Adults (M3AX)

Description

Aging-related functional declines are thought to be caused by hallmark biological processes that ultimately manifest in physical, mental, and metabolic impairments that compromise healthspan and quality of life. Exercise is a multipotent treatment with promise to mitigate most aging hallmarks, but there is substantial variability in exercisƒe responsiveness. Combining endurance and resistance training in alignment with public health guidelines will be used to better understand variable exercise responsiveness in older adults with the ultimate goal of improving each older adult's capacity to attain the many health benefits of exercise.

Conditions

Sarcopenia

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Study Overview

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Study Details

Study overview

Aging-related functional declines are thought to be caused by hallmark biological processes that ultimately manifest in physical, mental, and metabolic impairments that compromise healthspan and quality of life. Exercise is a multipotent treatment with promise to mitigate most aging hallmarks, but there is substantial variability in exercisƒe responsiveness. Combining endurance and resistance training in alignment with public health guidelines will be used to better understand variable exercise responsiveness in older adults with the ultimate goal of improving each older adult's capacity to attain the many health benefits of exercise.

Multidimensional Predictive Modeling to Understand Mechanisms of Exercise Response Heterogeneity in Older Adults

Multidimensional Predictive Modeling to Understand Mechanisms of Exercise Response Heterogeneity in Older Adults (M3AX)

Condition
Sarcopenia
Intervention / Treatment

-

Contacts and Locations

Pensacola

Florida Institute for Human and Machine Cognition, Pensacola, Florida, United States, 32502

Oklahoma City

Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, United States, 73104

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Male or female aged 60 or above
  • 2. Free of chronic disease
  • 3. No structured exercise program (2 or more bouts/wk) within previous 12 months
  • 4. Cognitively capable of providing informed consent
  • 1. Neuromuscular or musculoskeletal disorder that would limit ability to perform the exercise and/or testing bouts
  • 2. Cardiopulmonary disorders or reduced breathing capacity (FEV1 \< 80% expected)
  • 3. Metabolic diseases including markers of liver disease (ALT \> 52 U/l) and type 2 diabetes (HbA1C ≥ 6.5, fasting blood glucose ≥ 126 mg/dl)
  • 4. Any other disease or disorder that would influence exercise response (e.g., chronic kidney disease, dementia, current cancer diagnosis or within 2 yr remission, cerebrovascular disease)
  • 5. Any current infectious disease
  • 6. Life expectancy \< 1 year
  • 7. Insulin sensitizing/blood glucose lowering agents such as metformin
  • 8. High dose lipophilic statin (≥40 mg/d)
  • 9. Lidocaine allergy
  • 10. Regular tobacco use and/or vaping
  • 11. Excessive alcohol consumption (3 drinks/d or 7 drinks/wk for females; 4 drinks/d or 14 drinks/wk for males)
  • 12. BMI ≥ 30.0 kg/m2
  • 13. Unable to commit to \~6 months required to complete the study

Ages Eligible for Study

60 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Florida Institute for Human and Machine Cognition,

Marcas Bamman, PRINCIPAL_INVESTIGATOR, Florida Institute for Human and Machine Cognition

Study Record Dates

2029-07-01