RECRUITING

Blood Flow Restriction for Optimizing Balance in Parkinson's Disease

Conditions

Parkinson's Disease and Parkinsonism Blood flow restriction Instability resistance training Balance Strength Postural control

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This study is being done to understand how reducing blood flow (BRT) during balance-challenging strengthening exercises (instability resistance training, or IRT) can help improve symptoms of Parkinson's disease.

Official Title

Blood Flow Restriction for Optimizing Balance in Parkinson's Disease

Quick Facts

Study Start:2024-01-07

Study Completion:2026-03

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT06508801

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:40 Years to 85 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:No

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
1. Males and females between the ages 40 - 85 with a diagnosis of idiopathic Parkinson's Disease (PD) consistent with the United Kingdom PD society brain bank criteria, 2. in Hoehn and Yahr stage 2-4, 3. a score of ≥23 on the mini-Mental Scale Examination.	1. History of cardiovascular disease, uncontrolled hypertension (blood pressure ≥140/90 mmHg), orthostatic hypotension, deep-vein thrombosis, varicose veins, or rhabdomyolysis; 2. Ankle branchial index ≤ 0.9 or \> 1.3. 3. History of other neurological disorders affecting the central nervous system such as stroke, multiple sclerosis, tumors, amyotrophic lateral sclerosis or muscle disease such as muscular dystrophy, myopathy. 4. History of uncontrolled diabetes, severe osteoporosis, or cognitive impairment. 5. Body mass index above 40; such individuals are more likely to have poorer muscle function and more pain. 6. Absolute contraindications to exercise as per the American College of Sports Medicine (uncontrolled arrhythmias, third-degree heart block, recent electrocardiogram (EKG) changes, unstable angina, acute myocardial infarction, or acute congestive heart failure 7. Had surgery in the lower extremities within the past 6 months. 8. Pre-menopausal and not on birth control 9. Pregnant or planning to become pregnant within the course of the study 10. Plan to have major surgery within 2 months.

Inclusion Criteria

Exclusion Criteria

1. Males and females between the ages 40 - 85 with a diagnosis of idiopathic Parkinson's Disease (PD) consistent with the United Kingdom PD society brain bank criteria,
2. in Hoehn and Yahr stage 2-4,
3. a score of ≥23 on the mini-Mental Scale Examination.

1. History of cardiovascular disease, uncontrolled hypertension (blood pressure ≥140/90 mmHg), orthostatic hypotension, deep-vein thrombosis, varicose veins, or rhabdomyolysis;
2. Ankle branchial index ≤ 0.9 or \> 1.3.
3. History of other neurological disorders affecting the central nervous system such as stroke, multiple sclerosis, tumors, amyotrophic lateral sclerosis or muscle disease such as muscular dystrophy, myopathy.
4. History of uncontrolled diabetes, severe osteoporosis, or cognitive impairment.
5. Body mass index above 40; such individuals are more likely to have poorer muscle function and more pain.
6. Absolute contraindications to exercise as per the American College of Sports Medicine (uncontrolled arrhythmias, third-degree heart block, recent electrocardiogram (EKG) changes, unstable angina, acute myocardial infarction, or acute congestive heart failure
7. Had surgery in the lower extremities within the past 6 months.
8. Pre-menopausal and not on birth control
9. Pregnant or planning to become pregnant within the course of the study
10. Plan to have major surgery within 2 months.

Contacts and Locations

Study Contact

Anjali Sivaramakrishnan, PhD, PT

CONTACT

210-567-8626

sivaramakris@uthscsa.edu

Alyssa Main

CONTACT

210-567-8767

baezaa1@uthscsa.edu

Principal Investigator

Anjali Sivaramakrishnan, PhD, PT

PRINCIPAL_INVESTIGATOR

The University of Texas Health Science Center at San Antonio

Study Locations (Sites)

University of Texas Health Science Center at San Antonio

San Antonio, Texas, 78229

United States

Collaborators and Investigators

Sponsor: The University of Texas Health Science Center at San Antonio

Anjali Sivaramakrishnan, PhD, PT, PRINCIPAL_INVESTIGATOR, The University of Texas Health Science Center at San Antonio

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-01-07

Study Completion Date2026-03

Study Record Updates

Study Start Date2024-01-07

Study Completion Date2026-03

Terms related to this study

Keywords Provided by Researchers

Blood flow restriction
Instability resistance training
Balance
Strength
Postural control

Additional Relevant MeSH Terms

Parkinson's Disease and Parkinsonism