Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
For general information about clinical research, read Learn About Studies.
Eligibility Criteria
- * ≥18 yrs of age
- * Receiving SGLT2 inhibitors and spironolactone (and beta-blocker use for HFpEF patients with hypertension) for \>3 months
- * NYHA symptoms I-III
- * Body mass index ≤40 kg/m2
- * Currently non-smokers with \<20 pack year history
- * Able to exercise (i.e. without significant orthopedic limitations or musculoskeletal disorders limiting their ability to exercise)
- * Sustained ventricular tachycardia and/or ventricular fibrillation within 21 days of visit 1
- * Second or third degree heart block
- * Body mass index \>40 kg/m2
- * Current smokers and/or smoking history \>20 pack years
- * Pregnant women (testing will be done by research team if requested)
- * Glomerular filtration rate of \<30 mL/min/1.73m2 (initial screen via clinical record within the past 6 months and this will be assessed on Visit 1)
- * Individuals who are not able to engage in exercise
- * Uremia, history of allergy to iodides
- * Peripheral artery disease
- * Alanine transaminase and/or aspartate transaminase greater than 2 times the upper limit of normal (via clinical record within the past 6 months)
- * Asthmatic patients with a low symptom perception and suffer frequency, severe exacerbations or with an abnormally low perception of dyspnea
- * Ruptured eardrum or any other condition of the ear
- * History of spontaneous pneumothorax or osteoporosis with a history of rib fractures
- * History of lidocaine allergy.
Ages Eligible for Study
18 Years to
Sexes Eligible for Study
ALL
Accepts Healthy Volunteers
No